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The role of the interaction between integrin and TGF-beta in the eye wound healing

The role of the interaction between integrin and TGF-beta in the eye wound healing
整合素和TGF-β相互作用在眼部伤口愈合中的作用
批准号:
23592596
负责人:
YOSHIDA Koji
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
When corneal fibroblast (keratocyte) was stimulated by TGF-beta, the keratocytes showed myofibroblast-like morphology. In addition, the expression of integrin alpha11 (ITGA11), alpha-smooth muscle actin (alpha-SMA), fibronectin in keratocytes was increased by TGF-beta treatment. Sensitivity to TGF-beta was up-regulated in the cells constitutively expressing ITGA11 or calcium-and integrin-binding protein 1. It was suggested that ITGA11 and CIB1 could be the target protein of the organ fibrosis treatment.Furthermore, we found that the green tea component epigallocatechin-3-gallate (EGCG) binds to TGF-beta type II receptor and inhibits the action of TGF-beta.
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会议论文
TGF-beta2 promotes RPE cell invasion into collagen gel by mediating urokinase-type plasminogen activator (uPA) expression
TGF-β2 通过介导尿激酶型纤溶酶原激活剂 (uPA) 表达促进 RPE 细胞侵入胶原凝胶
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K., 直井信久, Sugioka K]
通讯作者: Sugioka K
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Uchida A, Shinoda K, Matsumoto C.S, Kawai M, Kawai S, Ohde H, Ozawa Y, Ishida S, Inoue M, Mizota A, Tsubota K., 吉田浩二]
通讯作者: 吉田浩二
線溶系遺伝子欠損マウスを用いた角膜上皮創傷治癒過程の検討
使用纤溶基因缺陷小鼠检查角膜上皮伤口愈合过程
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [小澤摩記,河野尚子,林孝彰,Jin Zi-Bing, 中馬秀樹,常岡寛,直井信久, 児玉彩]
通讯作者: 児玉彩
Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation.
来自肺癌细胞系 A549 和 PC9 的条件培养基通过调节蛋白质磷酸化来灭活肺成纤维细胞。
DOI: 10.1016/j.abb.2011.12.012
发表时间: 2012
期刊: Arch Biochem Biophys.
影响因子: --
作者: [Park AM, Hayakawa S, Honda E, Mine Y, Yoshida K, Munakata H.]
通讯作者: Munakata H.
6
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    • 财政年份:
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