The role of the interaction between integrin and TGF-beta in the eye wound healing
The role of the interaction between integrin and TGF-beta in the eye wound healing
批准号:
23592596
负责人:
YOSHIDA Koji
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
When corneal fibroblast (keratocyte) was stimulated by TGF-beta, the keratocytes showed myofibroblast-like morphology. In addition, the expression of integrin alpha11 (ITGA11), alpha-smooth muscle actin (alpha-SMA), fibronectin in keratocytes was increased by TGF-beta treatment. Sensitivity to TGF-beta was up-regulated in the cells constitutively expressing ITGA11 or calcium-and integrin-binding protein 1. It was suggested that ITGA11 and CIB1 could be the target protein of the organ fibrosis treatment.Furthermore, we found that the green tea component epigallocatechin-3-gallate (EGCG) binds to TGF-beta type II receptor and inhibits the action of TGF-beta.
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TGF-beta2 promotes RPE cell invasion into collagen gel by mediating urokinase-type plasminogen activator (uPA) expression
TGF-β2 通过介导尿激酶型纤溶酶原激活剂 (uPA) 表达促进 RPE 细胞侵入胶原凝胶
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M, Kawakita T, Tsubota K., 直井信久, Sugioka K]
通讯作者:
Sugioka K
マトリックスメタロプロテイナーゼ2はα_2-antiplasminを分解する
基质金属蛋白酶 2 降解 α_2-抗纤溶酶
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Uchida A, Shinoda K, Matsumoto C.S, Kawai M, Kawai S, Ohde H, Ozawa Y, Ishida S, Inoue M, Mizota A, Tsubota K., 吉田浩二]
通讯作者:
吉田浩二
線溶系遺伝子欠損マウスを用いた角膜上皮創傷治癒過程の検討
使用纤溶基因缺陷小鼠检查角膜上皮伤口愈合过程
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[小澤摩記,河野尚子,林孝彰,Jin Zi-Bing, 中馬秀樹,常岡寛,直井信久, 児玉彩]
通讯作者:
児玉彩
Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation.
来自肺癌细胞系 A549 和 PC9 的条件培养基通过调节蛋白质磷酸化来灭活肺成纤维细胞。
DOI:
10.1016/j.abb.2011.12.012
发表时间:
2012
期刊:
Arch Biochem Biophys.
影响因子:
--
作者:
[Park AM, Hayakawa S, Honda E, Mine Y, Yoshida K, Munakata H.]
通讯作者:
Munakata H.
原因不明の角膜潰瘍による角膜穿孔症例における線溶系因子の免疫学的局在の検討
不明原因角膜溃疡导致角膜穿孔时纤溶因子的免疫学定位检查
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y., 児玉彩]
通讯作者:
児玉彩
共 6 条
Comparative Linguistic Studies on the Acquisition of Referential Relations in Complement Clauses: with Some Emphases on Binding Relations in Japanese, Korean, and English
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批准号:15K02771
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Approach to radiation education for public health nurses in Fukushima Prefecture
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批准号:26861857
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资助金额:$1.25万
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Function of antifreeze protein and dynamic crossover of hydration water
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资助金额:$3.0万
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财政年份:2010
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依托单位:
A Study for Establishing an Accurate Estimation Method of Axle Weights for In-motion Vehicles with High Velocity by Using Miniature Experimental Models
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批准号:22560433
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2010
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负责人:YOSHIDA Koji
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Qualitative research about group activities for people with social withdrawal
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批准号:20790448
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资助金额:$1.66万
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财政年份:2008
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负责人:YOSHIDA Koji
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Roles of cytoskeletal proteins in organic fibrosis and their application of therapy in fibrotic diseases
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批准号:20592111
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.41万
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财政年份:2008
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负责人:YOSHIDA Koji
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Hypothesis of the second critical point of water and protein folding mechanism
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批准号:19750010
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资助金额:$2.57万
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Investigation of single-crystal growth and relationship between magnetoresistance and self-organization in double-perovskite oxides
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批准号:18560318
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资助金额:$1.87万
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财政年份:2006
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负责人:YOSHIDA Koji
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依托单位:
Research for the medical treatment of rheumatoid arthritis by endogenous inhibitor of aggrecanase
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批准号:13671550
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2001
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负责人:YOSHIDA Koji
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依托单位:
海外基金