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Hypothesis of the second critical point of water and protein folding mechanism

Hypothesis of the second critical point of water and protein folding mechanism
水与蛋白质折叠机制第二临界点假说
批准号:
19750010
负责人:
YOSHIDA Koji
金额:
$2.57万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
Dynamics of hydration water around proteins and confined water in nano-porous materials (silica and dextran gel) was measured with X-ray and neutron scattering experiments. The temperature behaviors in the relaxation time of confined water molecules in the porous silica change from the Ahrrenus type to the non-Ahrrenus one at around 220 K (fragile-strong transition) where the atomic motion of hydrated proteins changes from a harmonic to anharmonic behavior. From these results, the role of water in protein folding was discussed.
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On the solvent role in alcohol-induced α-helix formation ofchymotrypsin inhibitor-2
溶剂在酒精诱导胰凝乳蛋白酶抑制剂-2 α-螺旋形成中的作用
DOI: --
发表时间: 2008
期刊: Pure Appl. Chem 80
影响因子: --
作者: [K. Yoshida, J. Kawaguchi, S. Lee, T. Yamaguchi]
通讯作者: T. Yamaguchi
Thermodynamic, structural and dynamic properties of supercooled water confined in mesoporous MCM-41 studied with calorimetric, neutron diffraction and neutron spin echo measurements
通过量热、中子衍射和中子自旋回波测量研究了介孔 MCM-41 中限制的过冷水的热力学、结构和动力学特性
DOI: --
发表时间: 2008
期刊: J. Chem. Phys. 112
影响因子: --
作者: [南部伸孝, 徳江郁雄, 徳江 郁雄・南部 伸孝・山崎 勝義, 脇川 祐介・徳江 郁雄・南部 伸孝, 脇川 祐介・徳江 郁雄・南部 伸孝, 石田成, K. Yoshida, K. Yoshida]
通讯作者: K. Yoshida
Collective Dynamics of Hydrated Protein by Inelastic X-ray Scattering
非弹性 X 射线散射的水合蛋白质的集体动力学
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [K. Yoshida, T. Yamaguchi, S. Hosokawa, A.Q.R. Baron]
通讯作者: A.Q.R. Baron
中性子散乱および動的光散乱によるβ-ラクトグロブリンの構造と運動に対するアルコールの影響
中子散射和动态光散射研究酒精对β-乳球蛋白结构和运动的影响
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [安池智一, 信定克幸, 吉田亨次・山口敏男・遠藤仁・柴山充弘]
通讯作者: 吉田亨次・山口敏男・遠藤仁・柴山充弘
16
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    • 资助金额:
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    • 负责人:
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