Expression of a lipid-metabolizing enzyme, diacylglycerol kinase, after brain damage
Expression of a lipid-metabolizing enzyme, diacylglycerol kinase, after brain damage
批准号:
20592116
负责人:
KAWAMAE Kaneyuki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Diacyglycerol kinase (DGK) plays an important role in the intracellular signal transduction through the metabolism of a second messenger diacylglycerol. One of the DGK isozymes, DGKζ was originally shown to be expressed in neurons under physiological conditions. However, we found that under pathological conditions, a cryoinjury brain model, DGKζ-immunoreactivity is detected in activated microglia that phagocytose the debris after brain injury. These results suggest that DGK. participates in the remodeling of the brain after injury.
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Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta
二酰甘油激酶-zeta 中功能性核输出序列的鉴定
DOI:
--
发表时间:
2010
期刊:
Cell Cycle
影响因子:
4.3
作者:
[Evangelisti C, Gaboardi GC, Billi AM, Ognibene A, Goto K, Tazzari PL, McCubrey JA, Martelli AM.]
通讯作者:
Martelli AM.
Nucleocytoplasmic translocation of diacylglycerol kinase zeta under oxygen and glucose deprivation in rat hippocampal slices
大鼠海马切片缺氧和缺糖条件下二酰甘油激酶 zeta 的核细胞质转位
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki Y, Yamazaki Y, Kaneko K, Fujii S, Iseki K, Goto K]
通讯作者:
Goto K
The Tohoku ALI Study Group. A prospective cohort study of ALI/ARDS in the Tohoku district of Japan (second report)
东北 ALI 研究小组。
DOI:
--
发表时间:
2010
期刊:
J Anesth
影响因子:
2.8
作者:
[Endo S, Shibata S, Sato N, Hashiba E, Tajjimi K, Saito K, Kawamae K, Nakane M, Murakawa M]
通讯作者:
Murakawa M
嫌酒者によるメタノール中毒の1例
一起醉酒者甲醇中毒事件
DOI:
--
发表时间:
2009
期刊:
中毒研究
影响因子:
--
作者:
[伊関憲, 永野達也, 杉浦明日美, 金井雅代, 仁木敬夫, 堀寧, 川前金幸]
通讯作者:
川前金幸
Expression and subcellular localization of diacylglycerol kinase isozyme in rat aortic endothelial cells
二酰甘油激酶同工酶在大鼠主动脉内皮细胞中的表达及亚细胞定位
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[T. Nakano, K. Goto, I. Wakabayashi]
通讯作者:
I. Wakabayashi
共 32 条
Evaluation of the acute inflammation using macrophages
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批准号:24592323
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
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负责人:KAWAMAE Kaneyuki
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依托单位:
海外基金