Tooth root morphogenesis ? molecular and morphological analysis for multi-root formation

多根结构包括上皮性突起和髓下叶结构。用原位杂交、免疫组织化学和苏木精-伊红染色观察小鼠和大鼠多根的形成过程。因此，在多根形成过程中，一个特定的遗传级联控制上皮投射是相当重要的。此外，髓下叶形成岛状结构，在髓下叶形成过程中细胞分化类似于牙冠牙本质形成过程。

Multi-root formation consists of both epithelial projection and subpulpal lobe formation. The process of the multi-root formation was examined by in situ hybridization, immunohistochemistry and hematoxyline staining in mice and rats. As a result, it is considerable that a specific genetic cascade controlled epithelial projection during multi-root formation. Moreover, subpulpal lobes are formed island-like and cell differentiation during subpulpal lobe formation is similar to that of tooth crown dentin formation.