Clarification of role of smad regulating and promoting nodule formation in the dental pulp

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In order to widen the indications for conservative treatment of pulp, the purpose of this study was clarified the manner of smads which seem to facilitate the control of pulp nodule formation. During the addition of low concentration PGE2 to promote calcification, smad-7 was inhibited. Adding high concentration PGE2 to regulate calcification, smad-7 was enhanced. The laser irradiation to promote calcification is increased smad-1. The results suggested that to promote calcification smad-1 was enhanced and smad-7 was inhibited.