Clarification of role of smad regulating and promoting nodule formation in the dental pulp

为了拓宽牙髓保守治疗的适应证，本研究的目的是阐明SMADS的方式，它似乎有助于控制牙髓结节的形成。在加入低浓度PGE2促进钙化的过程中，Smad-7被抑制。加入高浓度PGE2调节钙化，Smad-7表达增强。激光照射促进钙化的Smad-1增加。结果提示，Smad-1促进钙化，而Smad-7抑制Smad-7促进钙化。

In order to widen the indications for conservative treatment of pulp, the purpose of this study was clarified the manner of smads which seem to facilitate the control of pulp nodule formation. During the addition of low concentration PGE2 to promote calcification, smad-7 was inhibited. Adding high concentration PGE2 to regulate calcification, smad-7 was enhanced. The laser irradiation to promote calcification is increased smad-1. The results suggested that to promote calcification smad-1 was enhanced and smad-7 was inhibited.