Pain sensations of oral region in rat models of Parkinson's disease

帕金森病模型大鼠口腔疼痛感觉

• 批准号: 20592371
• 负责人: NIWA Hitoshi
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592371/
• 关键词: パーキンソン病; 痛覚; 三叉神経; 疼痛関連行動; c-Fos; ホルマリンテスト; 痔痛関連行動; 疼痛感覚; ホルマチンテスト; 体性感覚誘発電位; ラット

Parkinson's disease model rats (PD rat) were injected formalin into the left upper lip. The numbers of pain-related-behavior (PRB) and c-Fos or ERK positive cells in the trigeminal nucleus caudalis were counted after formalin injection. PD rats with contralateral injection showed a decrease in PRB during the first 5 min, however, there was no significant change in ERK expression compared with sham rats. The number of PRBs and c-Fos expression increase in PD rats with ipsilateral injection. These results suggest that the PD rat is in hyperalgesia, however, the behavioral response to pain is blunted.

帕金森病模型大鼠(PD大鼠)左上唇注射福尔马林。注射福尔马林后，计数三叉神经尾侧核痛相关行为(PRB)和c-Fos、ERK阳性细胞数。与假手术组相比，对侧注射PD大鼠的pRb在前5min内显著降低，而ERK的表达无明显变化。同侧注射帕金森病大鼠后，pRB数目增加，c-Fos表达增加。这些结果表明帕金森病大鼠处于痛敏状态，但对疼痛的行为反应迟钝。

项目成果

Behavioral responses and Fos expression following facial painful stimuli in hemi-parkinsonian rats

偏侧帕金森病大鼠面部疼痛刺激后的行为反应和 Fos 表达

• 发表时间: 2010
• 作者: Maegawa H;Sugiyo A;Masawaki A;Oyamaguti A;Yoshida A;Kato T;Niwa H
• 通讯作者: Niwa H