权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The effects of acupuncture on endocrine system, autonomic nervous system and cerebral function

针灸对内分泌系统、自主神经系统及脑功能的影响

基本信息

批准号：
17592076
负责人：
NIWA Hitoshi
金额：
$ 2.18万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

(Aims)Acupuncture has been widely Used in clinical practice for the management of chronic pain. However, the mechanism of acupuncture is not clear. Because chronic pain is associated with alteration of autonomic nervous activity, we evaluated the effects of acupuncture on autonomic nervous activity.(Methods)Ten healthy adult volunteers were enrolled in the study. Heart rate (HR) and blood pressure (BP) were measured using electrocardiograph and tonometry. Control values were recorded after a 30-minute rest. Then acupuncture was applied at Hegu (L14) and Shousanli (LI10) on the right arm for 30 minutes. HR and BP were recorded continuously during and after the acupuncture. We analyzed the low frequency power of systolic blood pressure (SBP-LF) and the high frequency power of HR variability (HR-HF) by power spectral analysis. Moreover, we examined the effect of acupuncture on salivary secretion of chromogranin A(CgA) that was the good marker of emotional stress. As sham Stimulation, we evaluated the influence to each variable when stimulating non-acupuncture points.(Results)After the acupuncture, SBP-LF is reduced and HR-HF increased. These responses were associated the reduction of SBP and HR. CgA was not affected by the stimulation to acupuncture points, however increased by the stimulation of sham point.(Discussion and conclusion)Reduction in HR and SBP resulted from suppressed sympathetic nervous activity. Acupuncture at Hegu point and Shousanli point may affect the autonomic nervous system.

（目的）针灸已广泛应用于临床治疗慢性疼痛。然而，针灸的作用机制尚不清楚。由于慢性疼痛与自主神经活动的改变有关，我们评估了针灸对自主神经活动的影响。（方法）选取10名健康成人志愿者。心率（HR）和血压（BP）分别用心电图仪和血压计测量。休息30分钟后记录控制值。然后针刺右臂合谷穴（L14）、寿三里穴（LI10） 30分钟。针刺时和针刺后连续记录心率和血压。通过功率谱分析收缩压低频功率（SBP-LF）和心率变异性高频功率（HR- hf）。此外，我们还研究了针刺对唾液分泌嗜铬粒蛋白A（CgA）的影响，CgA是情绪应激的良好标志。作为假刺激，我们评估了刺激非穴位时对各变量的影响。（结果）针刺后SBP-LF降低，HR-HF升高。这些反应与收缩压和心率降低有关。CgA不受穴位刺激的影响，而受假穴位刺激的影响，CgA增加。（讨论与结论）交感神经活动抑制导致HR和收缩压降低。针刺合谷穴和寿三里穴可影响自主神经系统。