Influence of Duodeno-Gastro-Esophageal Reflux on Sleep Bruxism

以前的研究表明，睡眠磨牙症(SB)和胃食道反流之间存在联系；然而，这种关系从未被描述过。为了检验食道内酸化是否会诱发SB，我们进行了一项随机试验，比较了食道内注入5ml酸性溶液(0.1N HCl，pH 1.2)和注入生理盐水后咀嚼肌的活动。对12例无SB的健康成年男性进行了咬肌肌电多导睡眠图(EMG)、音像记录和食道pH监测。酸性肌注后20min肌电爆发频率、节律性咀嚼肌活动(RMMA)发作次数、碾压噪声和RMMA/微觉醒比值均显著高于生理盐水注药后。这些结果表明，包括SB在内的RMMA发作是由食管酸引起的。

Previous studies have suggested an association between sleep bruxism (SB) and gastroesophageal reflux ; however, the relationship has never been characterized. To examine whether intra-esophageal acidification induces SB, we conducted a randomized trial to compare masticatory muscle activity after intraesophageal infusion with 5 ml acidic solution (0.1 N HCl, pH 1.2) and infusion with saline. Polysomnography with electromyogram (EMG) of the masseter muscle, audio-video recording, and pH monitoring of the esophagus were performed in 12 healthy adult males without SB. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-min period after acidic infusion than after saline infusion. These results suggest that RMMA episodes including SB were induced by esophageal acidification.