Biological responses that eliminate invasive bacteria in the periodontal cells

一些牙周病原体具有侵袭牙龈上皮细胞的能力。这种能力被认为是导致牙周炎的机制之一。在本研究中，我们将重点关注已被证明在检测和消除侵袭性细菌方面发挥重要作用的NOD蛋白，并探讨NOD蛋白是否能够识别牙周病原体。结果发现，牙周病原菌的种类不同，NOD1和NOD2刺激活性也不同。

Some of periodontal pathogens have an ability to invade gingival epithelial cells. This ability is thought as one of the mechanism to induce periodontal inflammation. In the present study, we focus on NOD proteins that have been shown to play an important role on detection and elimination of invasive bacteria, and investigate whether NODs proteins can recognize periodontal pathogens or not. As results, we find both NOD1- and NOD2-stimulatory activities are different by the species of periodontal pathogens.