Development of apical tissue regeneration technology using human tooth germ derived cloning cell

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We aimed to develop apical tissue regeneration technology to restore root length that was lost due to root resorption or surgical root resection in the orthodontic treatment. As a result, we successfully reconstituted a bioengineered tooth germ for eruption using the organ germ method. We developed an animal model that reproduces root apical tissue regeneration and used this model to transplant the apical tissue from the bioengineered tooth germ, but were unable to observe engraftment of the tissue. Then, for the stabilization of the engraftment, I aimed at the transplant of the bioengineered tooth root of the same size. Currently, our experiments are ongoing to transplant the apical tissue from the bioengineered tooth of the same size, which was developed by transplantation in the sub-renal capsule, into the animal model.