Crosstalk between epithelial barrier function and cytokine signaling during salmonella infection

沙门氏菌感染期间上皮屏障功能和细胞因子信号传导之间的串扰

• 批准号: 20599015
• 负责人: INAGAKI Kyoko
• 金额: $ 2.54万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20599015/
• 关键词: 腸管上皮間T細胞; 腸管上皮バリア; 腸管寄生細菌; ジャンクション分子; サイトカイン; 腸管感染性細菌; サルモネラ; 腸管バリア; 上皮細胞; IEL

The intestinal epithelium has evolved structurally to form a barrier between the antigen-rich environment of the lumen and the sterile internal environment of the organism. In this study, we demonstrated that IEL has an important role in early protection against intestinal infection by S. typhimurium and DSS-induced colitis which the escape immediate early protection at the surface of intestinal epithelia. These results indicate that IEL play important multifunctional roles not only in protection of the epithelium against S. typhimurium or DSS-induced change by cytokine production but also in direct interaction with the epithelial barrier when intra-EC junctions are down-regulated.

肠上皮在结构上进化形成了一个屏障，在富含抗原的管腔环境和有机体无菌的内环境之间形成屏障。在本研究中，我们证明了IEL在预防鼠伤寒沙门氏菌和dss诱导的结肠炎的早期保护中具有重要作用，这些保护在肠上皮表面逃逸。这些结果表明，IEL不仅在保护上皮免受鼠伤寒沙门氏菌或dss诱导的细胞因子变化中发挥重要的多功能作用，而且在ec内连接下调时与上皮屏障直接相互作用。

项目成果

Increased intestinal endotoxin absorption during enteric nematode but not protozoal infections through a mast cell-mediated mechanism

• DOI: 10.1097/shk.0b013e31815c3f36
• 发表时间: 2008-06-01
• 期刊: SHOCK
• 影响因子: 3.1
• 作者: Farid, Ayman Samir;Jimi, Fumiko;Horii, Yoichiro
• 通讯作者: Horii, Yoichiro

Loss of suppressor of cytokine signaling-3 (SOCS3) in gastrointestinal epithelial cells results in gastric carcinoma

胃肠道上皮细胞中细胞因子信号传导抑制因子 3 (SOCS3) 的缺失导致胃癌

• 发表时间: 2008
• 作者: Kyoko Inagaki-Ohara;Akihiko Yoshimura;Seiya Kato;Goro Matsuzaki;稲垣匡子
• 通讯作者: 稲垣匡子

Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in dextran sulphate sodium-administered mice.

肾上腺髓质素治疗可减轻右旋糖酐硫酸钠给药小鼠的肠道炎症并维持上皮屏障功能。

• 发表时间: 2009
• 期刊: Microbiol.Immunol. 53
• 作者: Ashizuka S.;Inagaki-Ohara K.;Kuwasako K.;Kato J.;Inatsu H.;Kitamura K.
• 通讯作者: Kitamura K.

Loss of SOCS3 in gastrointestinal epithelial cells enhances leptin-mediated signaling and confers gastric cancer

胃肠道上皮细胞中 SOCS3 的缺失会增强瘦素介导的信号传导并导致胃癌

• 发表时间: 2009
• 作者: Shinya Ashizuka;et.al.;Farid A. S;Kyoko Inagaki-Ohara;Kyoko Inagaki-Ohara;Kyoko Inagaki-Ohara
• 通讯作者: Kyoko Inagaki-Ohara

Interleukin-17A is required to suppress invasion of Salmonella enterica serover Typhimurium to enteric mucosa.

Interleukin-17A 是抑制肠沙门氏菌血清鼠伤寒侵入肠粘膜所必需的。

• 发表时间: 2010
• 期刊: Immunology 131
• 作者: Mayuzumi H.;Inagaki-Ohara K.;Uyttenhove C.;Okamoto Y.;Matsuzaki G.
• 通讯作者: Matsuzaki G.