Crosstalk between epithelial barrier function and cytokine signaling during salmonella infection

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The intestinal epithelium has evolved structurally to form a barrier between the antigen-rich environment of the lumen and the sterile internal environment of the organism. In this study, we demonstrated that IEL has an important role in early protection against intestinal infection by S. typhimurium and DSS-induced colitis which the escape immediate early protection at the surface of intestinal epithelia. These results indicate that IEL play important multifunctional roles not only in protection of the epithelium against S. typhimurium or DSS-induced change by cytokine production but also in direct interaction with the epithelial barrier when intra-EC junctions are down-regulated.