Establishment of tools for assessing the effect of endocrine-disrupting chemicals on brain development in non-human primates

本研究旨在建立有效的工具来评估内分泌干扰物质对食蟹猴大脑发育的影响，因为食蟹猴在系统发育上与人类接近。本研究发现，在出生后3 ~ 60天，甲状腺激素合成抑制剂（甲巯咪唑）注射引起的甲状腺激素全体性减少延迟了抑制性神经传递系统的发育，此时神经发育显著加快。本研究建立了一些体外工具，利用食蟹猴的神经细胞来评估内分泌干扰物质对大脑发育的影响

This study aimed to establish effective tools for assessing the effect of endocrine-disrupting chemicals on brain development in cynomolgus monkey, because cynomolgus monkey is phylogenetically close to human. This study revealed that development of inhibitory neurotransmission system delayed by systemic reduction of thyroid hormone induced by thyroid hormone synthesis inhibitor (methimazole) injection from three to 60 days after birth, when neural development dramatically proceeded. And this study established some in vitro tools using neural cells derived from cynomolgus monkey for assessing the effect of endocrine-disrupting chemicals on brain development