Mechanisms of hemolysis caused by anti-erythrocyte antibodies in the pathological condition of canine babesiosis.

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In canine babesiosis, antibodies that reacted with canine heat shock protein 70 (hsp70) were detected in dog sera. Because hsp70 from Babesia parasites showed high homology with canine hsp70, anti-Babesia parasite hsp70 antibody might cross-react with canine hsp70. Since canine hsp70 was expressed in canine erythrocytes, it was possible that anti-hsp70 antibodies in dog sera would be anti-erythrocyte membrane antibodeis ; however, canine hsp70 was not found on the membrane surface of erythrocytes, suggesting that erythrocytes would not be targets of anti-hsp70 antibody.