Mechanisms of hemolysis caused by anti-erythrocyte antibodies in the pathological condition of canine babesiosis.

犬巴贝西虫病病理状态下抗红细胞抗体引起的溶血机制。

• 批准号: 20688014
• 负责人: YAMASAKI Masahiro
• 金额: $ 6.66万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20688014/
• 关键词: イヌバベシア症; 抗赤血球抗体; heat shock protein 70; バベシア原虫; 貧血; Heat shock protein 70

In canine babesiosis, antibodies that reacted with canine heat shock protein 70 (hsp70) were detected in dog sera. Because hsp70 from Babesia parasites showed high homology with canine hsp70, anti-Babesia parasite hsp70 antibody might cross-react with canine hsp70. Since canine hsp70 was expressed in canine erythrocytes, it was possible that anti-hsp70 antibodies in dog sera would be anti-erythrocyte membrane antibodeis ; however, canine hsp70 was not found on the membrane surface of erythrocytes, suggesting that erythrocytes would not be targets of anti-hsp70 antibody.

在犬巴贝斯虫病中，在犬血清中检测到与犬热休克蛋白70（hsp70）反应的抗体。由于巴氏疟原虫hsp70与犬hsp70具有较高的同源性，因此抗巴氏疟原虫hsp70抗体可能与犬hsp70发生交叉反应。由于犬hsp70在犬红细胞中表达，因此犬血清中的抗hsp70抗体可能是抗红细胞膜抗体，但在红细胞膜表面未发现犬hsp70，提示红细胞不是抗hsp70抗体的靶细胞。

项目成果

Retrospective diagnosis of feline GM2 gangliosidosis variant 0 (Sandhoff-Like disease) in Japan: Possible spread of the mutant allele in the Japanese domestic cat population

• DOI: 10.1292/jvms.70.813
• 发表时间: 2008-08-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Yamato, Osamu;Hayashi, Daisuke;Arai, Toshiro
• 通讯作者: Arai, Toshiro

EFFECTS AND MECHANISMS OF ACTION OF IONOPHOROUS ANTIBIOTICS VALINOMYCIN AND SALINOMYCIN-NA ON BABESIA GIBSONI IN VITRO

• DOI: 10.1645/ge-2036.1
• 发表时间: 2009-12-01
• 期刊: JOURNAL OF PARASITOLOGY
• 影响因子: 1.3
• 作者: Yamasaki, Masahiro;Nakamura, Kensuke;Takiguchi, Mitsuyoshi
• 通讯作者: Takiguchi, Mitsuyoshi

Detection of anti-Babesia gibsoni heat shock protein 70 antibody and anti-canine heat shock protein 70 antibody in sera from Babesia gibsoni-infected dogs

吉氏巴贝虫感染犬血清中抗吉氏巴贝虫热休克蛋白70抗体和抗犬热休克蛋白70抗体的检测

• DOI: 10.1016/j.vetpar.2011.03.006
• 发表时间: 2011
• 期刊: Veterinary Parasitology
• 影响因子: 2.6
• 作者: Yamasaki M;Nakamura K;et al
• 通讯作者: et al

Babesia gibsoni : Detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis

吉氏巴贝虫：使用脱氧核糖核酸原位杂交分析检测血涂片和福尔马林固定、石蜡包埋的组织

• 发表时间: 2011
• 期刊: Experimental parasitology
• 影响因子: 2.1
• 作者: Naoyuki Yokoyama;藤本卓也;Yamasaki M
• 通讯作者: Yamasaki M

Development and Characterization of a Strain of Babesia gibsoni Resistant to Diminazene Aceturate In Vitro

• DOI: 10.1292/jvms.09-0535
• 发表时间: 2010-06-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Hwang, Shiang-Jyi;Yamasaki, Masahiro;Takiguchi, Mitsuyoshi
• 通讯作者: Takiguchi, Mitsuyoshi