Multi-unit operation in the single neuron

单个神经元的多单元操作

• 批准号: 20700277
• 负责人: WATANABE Hidenori
• 金额: $ 2.83万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700277/
• 关键词: 生体情報; 錐体細胞; 樹状突起; 膜電位応答; White noise電流刺激; 神経細胞

Noise current stimulations were applied to rat hippocampal CA1 pyramidal cell dendrite in the acute and measured a membrane potential by Whole-cell Patch clamp. As a result of frequency response analysis, the dendrites had the characteristic of the low pass filter. In addition, heterogeneous distributions of the electrical impedance were shown on the dendrites, and there were the highest value in the intermediate segment of the dendrite. My results suggest that apical dendrites of hippocampal CA1 pyramidal cells integrate synaptic inputs, according to the frequency components of the input signal, along the dendritic segments receiving the inputs.

用噪声电流刺激急性期大鼠海马CA1锥体细胞树突，用全细胞膜片钳测量膜电位。频率响应分析表明，树突具有低通滤波器的特性。此外，枝晶上的电阻抗呈非均匀分布，且枝晶中间段的电阻抗最高。我的研究结果表明，海马CA1锥体细胞的顶端树突根据输入信号的频率成分，沿着接受输入的树突节段整合突触输入。