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霊長類の大脳皮質錐体細胞シナプス形態の領野特異性とその生後発達

灵长类大脑皮层锥体细胞突触形态的区域特异性及其出生后发育

基本信息

批准号：
15J05524
负责人：
小賀智文
金额：
$ 2.3万
依托单位：
National Center of Neurology and Psychiatry (2017)Osaka University (2015-2016)
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2015
资助国家：
日本
起止时间：
2015-04-24 至 2018-03-31
项目状态：
已结题

项目摘要

本研究計画において霊長類を対象にした研究論文を2報発表した。まず、一次視覚野の視野地図と樹状突起形態の関連を調査し、錐体細胞の基底樹状突起が一次視覚野内で均一であることを示した（Oga, Okamoto, Fujita, 2016）。この成果は、一次視覚野における視野表現が偏心度によりゆがんでいることの原因が、情報を受け取る一次視覚野３層細胞側にあるのではなく、入力線維の軸索の分枝の仕方にあることを示唆している。視野表現成立の神経機構の理解を大きく進めた。もう一つは錐体細胞の形態とスパイン密度の発達変化を大脳皮質5層においても調査し、3層細胞に関する先行研究成果（Elston, Oga, Fujita, 2009）と合わせて、錐体細胞の基底樹状突起が領野と層それぞれに特有の発達過程を経て成熟することを明確にした（Oga, Elston, Fujita, 2017）。本研究の成果は、ヒトの脳では実現できない精度での解析を行うことで初めて得られた。今後、ヒト脳の発達、発達異常、老化、疾患に伴う神経細胞の形態変化を評価する基盤を提供する重要な成果である。スパイン形態の領野間比較研究のデータ解析も順調に進行しており、成体サルの解析は終了し、連合野では視覚連合野TEだけでなく、前頭連合野12vlでも樹状突起スパインの大きさの多様性がV1より大きいことが明らかになった。現在、投稿準備中である。

This research project aims at the development of a new type of research paper. Investigation of the relationship between the morphology of dendrites in the primary visual field and basal dendrites in pyramidal cells (Oga, Okamoto, Fujita, 2016) The result is that the primary visual field shows eccentricity, the information is received, the primary visual field has three layers of cells, and the axis branches of the force line are branched. Vision performance is established and the understanding of mental institutions is greatly improved. The results of previous research that investigated the development and changes in the morphology and density of pyramidal cells in the fifth layer of the cortex and related to the third layer of cells (Elston, Oga, Fujita, 2009) are combined with the results of previous research that clarified that the unique development process of the basal dendrites of pyramidal cells is mature in the collar field and layers (Oga, Elston, Fujita, 2017). The results of this study are as follows: In the future, the development and development of abnormal, aging, disease associated with the morphological changes of neurons will provide important results. A comparative study of the morphology of the two regions was carried out. The analysis of the adult region was carried out in sequence. The analysis of the adult region was carried out in the end. The joint region was divided into two regions. The first region was divided into two regions. The first region was divided into two regions. The second region was divided into three regions. The first region was divided into two regions. The second region was divided into three regions. The third region was divided into three regions. The fourth region was divided into four regions. The fourth region was divided into three regions. The fourth region was divided into four regions. The fourth region was divided into three regions. The fourth region was divided into four regions. The fourth region was divided into three regions. The fourth region was divided into four regions. The fourth region was Currently, submission preparation is underway.