Characterization of neuronal cytokine Cbln

神经元细胞因子 Cbln 的表征

• 批准号: 20700295
• 负责人: IIJIMA Takatoshi
• 金额: $ 2.83万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700295/
• 关键词: C1q; brain; Mouse; cytokine; Cbln; hippocampus; inferior olive; 小脳; シナプス形成; Clq; シナプス可塑性; サイトカイン; TNF-aスーパーファミリー

C1q family, which is characterized by the C-terminal globular C1q (gC1q) domain, plays important roles in various intercellular processes. In addition, some of the C1q family members are expressed in the central nervous system. There are increasing evidences for the biological significance of C1q family in neurons. Nevertheless, their functions of C1q family proteins in CNS still remain unclear. Here we characterized C1q-like (C1ql) protein subfamily. These results indicate that, like Cbln subfamily, C1ql subfamily members may serve as a neuronal cytokine for synaptic functions in various brain regions.

C1q家族以c端球状C1q （gC1q）结构域为特征，在多种细胞间过程中发挥重要作用。此外，一些C1q家族成员在中枢神经系统中表达。越来越多的证据表明C1q家族在神经元中的生物学意义。然而，C1q家族蛋白在中枢神经系统中的功能尚不清楚。在这里，我们表征了c1q样（C1ql）蛋白亚家族。这些结果表明，与Cbln亚家族一样，C1ql亚家族成员可能在大脑不同区域的突触功能中发挥神经元细胞因子的作用。

项目成果

Activity-dependent repression of Cblnl expression : Mechanism for develo nmental and homeostatic regulation of synapses in the cerebellum

Cblnl 表达的活动依赖性抑制:小脑突触的发育和稳态调节机制

• 发表时间: 2009
• 期刊: The Journal of Neuroscience (In press)
• 作者: Takatoshi Iijima;Kyoichi Emi;Michisuke Yuzaki.;Takatoshi Iijima;Takatoshi Iijima
• 通讯作者: Takatoshi Iijima

Dept, of Physiology, Keio University, School of Medicine

庆应义塾大学医学院生理学系

• 发表时间: 2008
• 作者: Takatoshi Iijima;Michisuke Yuzaki
• 通讯作者: Michisuke Yuzaki

Calcium-dependent regulation of chln1 gene-a possible mechanism supporting hemeostatic plasticity in the cerebellum

chln1基因的钙依赖性调节——支持小脑止血可塑性的可能机制

• 发表时间: 2008
• 作者: Takatoshi Iijima;Kyoichi Emi;Michisuke Yuzaki.;Takatoshi Iijima;Takatoshi Iijima;Keiko Matsuda;Aya Ito-Ishida;Takatoshi Iijima
• 通讯作者: Takatoshi Iijima

Cbln1 binds to specific postsynaptic sites at parallel fiber–Purkinje cell synapses in the cerebellum

• DOI: 10.1111/j.1460-9568.2009.06639.x
• 发表时间: 2009-02
• 期刊: European Journal of Neuroscience
• 影响因子: 3.4
• 作者: K. Matsuda;T. Kondo;Takatoshi Iijima;S. Matsuda;Masahiko Watanabe;M. Yuzaki

Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins

• DOI: 10.1111/j.1460-9568.2010.07202.x
• 发表时间: 2010-05-01
• 期刊: EUROPEAN JOURNAL OF NEUROSCIENCE
• 影响因子: 3.4
• 作者: Iijima, Takatoshi;Miura, Eriko;Yuzaki, Michisuke
• 通讯作者: Yuzaki, Michisuke