Characterization of neuronal cytokine Cbln

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C1q family, which is characterized by the C-terminal globular C1q (gC1q) domain, plays important roles in various intercellular processes. In addition, some of the C1q family members are expressed in the central nervous system. There are increasing evidences for the biological significance of C1q family in neurons. Nevertheless, their functions of C1q family proteins in CNS still remain unclear. Here we characterized C1q-like (C1ql) protein subfamily. These results indicate that, like Cbln subfamily, C1ql subfamily members may serve as a neuronal cytokine for synaptic functions in various brain regions.