The RNA-based mechanism underlying pathophysiology in the neurodevelopmental disorders

神经发育障碍病理生理学中基于 RNA 的机制

• 批准号: 15K14355
• 负责人: IIJIMA Takatoshi
• 金额: $ 2.5万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K14355/
• 关键词: 自閉症スペクトラム障害; バルプロ酸; 抑制性神経細胞; シナプス; RNA制御; 発達障害; 自閉症; 精神疾患

项目成果

Molecular mechanism of alternative pre-mRNA splicing on neuronal cell adhesion molecules regulated by STAR family proteins

STAR家族蛋白调控神经细胞粘附分子前体mRNA选择性剪接的分子机制

• 发表时间: 2016
• 作者: Chiharu Hidaka;Noriko Ayukawa;Satoko Suzuki;Yoko Hanno-Iijima;Peter Scheiffele and Takatoshi Iijima
• 通讯作者: Peter Scheiffele and Takatoshi Iijima

Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.

• DOI: 10.1038/s41598-017-11319-5
• 发表时间: 2017-09-12
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Suzuki S;Ayukawa N;Okada C;Tanaka M;Takekoshi S;Iijima Y;Iijima T
• 通讯作者: Iijima T

Alternative splicing of Neurexin plays a crucial role in Neuroligin-induced presynaptic differentiation on cerebellar GABAergic neurons in vitro

Neurexin 的选择性剪接在 Neuroligin 诱导的体外小脑 GABA 能神经元突触前分化中起着至关重要的作用

• 发表时间: 2017
• 作者: Yuji Sato;Satoko Suzuki;Yoko Iijima and Takatoshi Iijima.
• 通讯作者: Yoko Iijima and Takatoshi Iijima.

Molecular mechanism and function of alternative pre-mRNA splicing on neuronal cell adhesion molecules regulated by STAR family proteins

STAR家族蛋白调控神经细胞粘附分子选择性前体mRNA剪接的分子机制和功能

• 发表时间: 2017
• 作者: Takatoshi Iijima

Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways.

• DOI: 10.1371/journal.pone.0134296
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hanno-Iijima Y;Tanaka M;Iijima T
• 通讯作者: Iijima T