Inhibitory Effect of a Combination of Thermotherapy with Exercise Therapy on Progression of Muscle Atrophy

热疗法与运动疗法相结合对肌肉萎缩进展的抑制作用

• 批准号: 20700450
• 负责人: SAKAGUCHI Akira
• 金额: $ 2.75万
• 依托单位: Hyogo University of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700450/
• 关键词: 理学療法学; 理学療法; 温熱療法; 運動療法; 物理療法

[Purpose] This study was performed to investigate the inhibitory effect of a short-term thermal load in combination with treadmill running or neuromuscular electrical stimulation on the progression of disuse muscle atrophy and its causative mechanism. [Subjects and Methods] The ankle joints of Wistar rats were fixed at maximum plantar flexion, and the fixation was removed for intervention once a day. The rats were divided into 6 groups for intervention : control, fixation, treadmill running, thermal treadmill running, neuromuscular electrical stimulation, and thermal neuromuscular electrical stimulation groups. [Results] The progression of disuse muscle atrophy was inhibited only in the group given a thermal load before treadmill running. Regarding the atrophy mechanism, the expression of heat shock protein 72, which promotes protein synthesis and repair, was enhanced, while the expression of protein ligase E3, which promotes protein degradation, was inhibited. [Conclusion] These findings suggest that thermotherapy prior to exercise therapy promotes the effect of exercise therapy in patients with disuse muscle atrophy and elderly persons.

[目的]探讨短期热负荷联合跑台运动或神经肌肉电刺激对废用性肌萎缩的抑制作用及其机制。[对象与方法]将Wistar大鼠踝关节固定于最大跖屈位，每天1次解除固定进行干预。将大鼠分为6组进行干预：对照组、固定组、跑台组、热跑台组、神经肌肉电刺激组和热神经肌肉电刺激组。[结果]跑台运动前给予热负荷组大鼠废用性肌萎缩的进程受到抑制。关于萎缩机制，促进蛋白质合成和修复的热休克蛋白72的表达增强，而促进蛋白质降解的蛋白质连接酶E3的表达受到抑制。[结论]运动疗法前热疗可促进废用性肌萎缩患者和老年人运动疗法的效果。

项目成果

Indication and Limitation of the Two Dimention Motion analyasis

二维运动分析的适应症和局限性

• 发表时间: 2008
• 作者: Akira Sakaguchi;et.al.
• 通讯作者: et.al.

Indication and Limitation of the Two Dimention Motion Analysis.

二维运动分析的指示和局限性。

• 发表时间: 2008
• 作者: Akira Sakaguchi;Hiroshi Maeoka;Shusaku Kanai;Masaki Hasegawa;Koji Shimatani;Yuki Kawahara;Tomofumi Uzaki.
• 通讯作者: Tomofumi Uzaki.

Inhibitory effect of a combination of thermotherapy with exercise therapy on progression of muscle atrophy

• 发表时间: 2010
• 作者: 坂口 顕