Direct observation of clustered DNA damage using time-of-flight ion mass spectrometer
Direct observation of clustered DNA damage using time-of-flight ion mass spectrometer
批准号:
20710048
负责人:
FUJII Kentaro
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To investigate the production mechanism of clustered DNA damage, I developed the time-of-flight ion mass spectrometer. If the two ions were produced by a single photon, the coincidence signal can be detected on the ion mass spectrum. Moreover, I measured the clustered DNA lesions induced by monochromatic soft X-rays by an enzymatic method.
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酸素K殻共鳴励起によりプラスミドDNA中に生成する鎖切断、塩基変異及びAPサイト
氧 K 壳共振激发在质粒 DNA 中产生链断裂、碱基突变和 AP 位点
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Gao Y., Xue Q., Omori K., Shimizu K., Utsumi M., Sugiura N., 筒井俊雄, 高村ゆかり, Okamoto N., 菅谷雄基]
通讯作者:
菅谷雄基
A Qualitative Analysis on the Yield of Radiation-induced DNA Strand Breaks in Hydrated Plasmids
水合质粒中辐射诱导 DNA 链断裂产量的定性分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[N. Shikazono, A. Urushibara, K. Fujii, A. Yokoya]
通讯作者:
A. Yokoya
Nucleobase Lesions and Strand Breaks in Dry DNA Thin Films Selectively Induced by Monochromatic Soft X-rays.
单色软 X 射线选择性诱导干 DNA 薄膜中的核碱基损伤和链断裂。
DOI:
--
发表时间:
2009
期刊:
Journal of Physical Chemistry B 113
影响因子:
--
作者:
[K.Fujii, N.Shikazono, A.Yokoya]
通讯作者:
A.Yokoya
DOI:
10.1016/j.radphyschem.2009.07.023
发表时间:
2009-12-01
期刊:
RADIATION PHYSICS AND CHEMISTRY
影响因子:
2.9
作者:
[Fu, Haiying, Katsumura, Yosuke, Hatano, Yoshihiko]
通讯作者:
Hatano, Yoshihiko
Near Edge X-ray absorption fine structure of DNA thin film irradiated with soft X-rays
软X射线照射DNA薄膜的近边X射线吸收精细结构
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[金广哲, ら, 西澤明人,杉山敬亮,有川淳,千田美紀,千田俊哉,福田雅夫,木村成伸, Sanae Chiba, Fuchida S., K. Fujii and A. Yokoya]
通讯作者:
K. Fujii and A. Yokoya
共 51 条
Control of Biological Effect by Altered ATP induced with Synchrotron Soft X-rays
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批准号:24310074
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2012
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负责人:FUJII Kentaro
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依托单位:
Study of Biological Effect induced by Radiation Damage of non-DNA Molecules
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批准号:24651057
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2012
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负责人:FUJII Kentaro
-
依托单位:
海外基金