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Study of Biological Effect induced by Radiation Damage of non-DNA Molecules

Study of Biological Effect induced by Radiation Damage of non-DNA Molecules
非DNA分子辐射损伤生物学效应的研究
批准号:
24651057
负责人:
FUJII Kentaro
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
ATP (Adenosine tri-phosphate), one of ribonucleic acids, acts as an intra-cellular energy transfer. ATP is also used as a substrate to synthesize messenger RNA and as a ligand of inter-cellular signaling. Damaged ATP produced by ionizing radiations might act as down- or up-regulation of these biological function. In this study, we examined the relation between molecular damage of ATP and its biological activity by using various biological assessments, such as energy donor activity, genetic information transfer, and inter-cellular signaling activity.
期刊论文(66)
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会议论文
Induction of DNA damage, including abasic sites, in plasmid DNA by carbon ion and X-ray irradiation
通过碳离子和 X 射线照射在质粒 DNA 中诱导 DNA 损伤,包括脱碱基位点
DOI: 10.1007/s00411-012-0447-4
发表时间: 2013
期刊: Radiat. Environ. Biophys.
影响因子: --
作者: [Shiina, T.]
通讯作者: T.
軟X線による水和デオキシリボースの分解過程
软X射线水合脱氧核糖分解过程
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [藤井健太郎, 泉雄大, 成田あゆみ, 横谷明徳]
通讯作者: 横谷明徳
DNA damage responses to external and internal low dose radiation
DNA 损伤对外部和内部低剂量辐射的反应
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [M. Katsura, H. Nakamine, S. Amagasa, N. Akimitsu, K. Miyagawa, Y. Wada]
通讯作者: Y. Wada
DOI: --
发表时间:
期刊:
影响因子: --
作者: [柴山祥枝, 藤井紳一郎, 高津章子]
通讯作者: 高津章子
42
    Control of Biological Effect by Altered ATP induced with Synchrotron Soft X-rays
    • 批准号:
      24310074
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.32万
    • 财政年份:
      2012
    • 负责人:
      FUJII Kentaro
    • 依托单位:
    Direct observation of clustered DNA damage using time-of-flight ion mass spectrometer
    • 批准号:
      20710048
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2008
    • 负责人:
      FUJII Kentaro
    • 依托单位:
    海外基金