Chemical synthesis of unique AG-gangliosides and evaluations of nerve cell stimulation activities

点击翻译按钮获取中文摘要

Gangliosides isolated from starfish have unique glycan sequences and nerve cell stimulating activities. We focused on their unique glycan sequences and synthesized the glycan parts by developing novel sialylation strategies. Further, we analyzed the binding between a starfish glycan and a protein Siglec, expressing on mammalian cell surfaces and modulating their functions. We elucidated the binding epitope as the trisaccharide unit including the sialic acid residue. Our finding revealed the potential that inner sialic acid could be also recognized by Siglec, which would develop useful potential for inhibitors of Siglec.