Chemical approach for elucidating structure and function of a novel glycolipid stimulating the membrane-protein integration.

膜蛋白与脂膜的整合受转位子的严格调控，如SecYEG复合物和YidC。最近，在这一整合过程中发现了一种新的整合刺激因子，可能是一种糖脂。本研究成功地从大肠杆菌中提取并纯化了该因子。coli菌株MC 4100中的一个整合因子，并通过NMR和MS分析获得的结构数据假定该整合因子的总结构。

Integration of membrane-proteins into lipid membranes is strictly regulated with translocon, such as SecYEG complex and YidC. Recently, a novel integration-stimulating factor, suggested a sort of glycolipid, was found out in this integration process. In this study, we succeeded in extraction and purification of this factor from E. coli strain MC4100 and assumed a total structure of this integration factor by structural data obtained by NMR and MS analyses.