Analysis of Protein Internal Motion from Viewpoint of Robot Kinematics

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We investigated algorithms for calculating the characteristics of the internal motion of proteins from a view point of robot kinematics. First, by using simplified artificial protein model, we derived algorithms for analyzing conformational fluctuation and force response. Then, we analyzed the internal motions of a real protein (Lactoferrin) by applying the algorithms to its three dimensional structural data, and obtained results which agree to the known measured internal motions.