Does the liver transplant from fatty liver become possible?- Ischemia reperfusion injury and liver transplantation model in rat.

脂肪肝肝移植可能吗？-大鼠缺血再灌注损伤及肝移植模型。

• 批准号: 20890105
• 负责人: KISHIWADA Masashi
• 金额: $ 1.7万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890105/
• 关键词: 虚血再灌流障害; トロンボモジュリン; 肝細胞; 類洞内皮細胞; Kuppfer細胞; 凝固・抗凝固因子; 炎症性サイトカイン; 脂肪肝; 炎症反応; 虚血再還流障害; 類洞内皮障害; TM; ラット; 肝移植; 細胞単離; 微小循環障害

rhsTM is useful for prevention of the HEPs and SECs damage and KCs activation induced by ischemia reperfusion injury. Our present study also suggests that disturbance of hepatic microcirculation is induced in part by intrasinusoidal microthrombus formation and by locally released inflammatory cytokines from KCs.

rhsTM对缺血再灌注损伤诱导的HEP和SEC损伤及KCs活化有保护作用。我们目前的研究还表明，肝微循环障碍的部分原因是由窦内微血栓形成和局部释放的炎症细胞因子从KC。

项目成果

The Cytoprotective Effects of Addition of Activated Protein C into Preservation Solution on Small-for-Size Grafts in Rats

• DOI: 10.1002/lt.21923
• 发表时间: 2010-01-01
• 期刊: LIVER TRANSPLANTATION
• 影响因子: 4.6
• 作者: Kuriyama, Naohisa;Isaji, Shuji;Suzuki, Koji
• 通讯作者: Suzuki, Koji

The Effect of Thrombomodulin on liver cells in Hepatic Ischemia Reperfusion Injury

血栓调节蛋白对肝缺血再灌注损伤中肝细胞的影响

• 发表时间: 2009
• 作者: Kuriyama N;Isaji S;Hamada T;Kishiwada M;Ohsawa I;Usui M;Sakurai H;Tabata M;Hayashi T;Suzuki K.;岸和田昌之
• 通讯作者: 岸和田昌之