Anatomical and functional analysis of medial preoptic area of hypothalamus, the center of mammalian parental behavior

哺乳动物亲代行为中心下丘脑内侧视前区的解剖学和功能分析

• 批准号: 20890287
• 负责人: YOSHIDA Sachine
• 金额: $ 2.41万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890287/
• 关键词: 養育行動; ノックアウトマウス; 視床下部; 内側視索前野; Anterior commissural nucleus(ACN); マウス

The brain center of parental behavior is believed to locate in the medial preoptic area (MPOA) of hypothalamus. The present study demonstrated that neurons of anterior commissural nucleus in the dorsolateral MPOA showed the activation during the parental behavior in mice. ACN contained oxytocin (OXT) and thyrotropin-releasing hormone (TRH) immunoreactive neurons. We examined the parental behavior using OXT or TRH knockout mice and double knockout mice. Nest building and pup retrieving behaviors were used as an index for the evaluation of parental behavior. In the preliminary results, however, any significant difference in the parental behavior of the OXT and TRH double knockout mice could not be detected. Further studies with higher sensitivity will be needed in future.

父母行为的脑中枢位于下丘脑内侧视前区（MPOA）。本研究表明，小鼠MPOA背外侧前连合核神经元在亲行为过程中有激活。ACN内含有催产素（OXT）和促甲状腺激素释放激素（TRH）免疫反应阳性神经元。我们使用OXT或TRH基因敲除小鼠和双基因敲除小鼠检查了亲代行为。巢建设和幼犬检索行为被用来作为一个指标的评价父母的行为。然而，在初步结果中，不能检测到OXT和TRH双敲除小鼠的亲本行为的任何显著差异。今后还需要进行更高灵敏度的进一步研究。

项目成果

Behavioral and anatomical characterization of mouse pup response to maternal transport

小鼠幼崽对母体运输反应的行为和解剖学特征

• 发表时间: 2009
• 作者: 林真由美;中村昭代鹿野佐代子;田中洋介;田中洋介;坂野聡美;坂野聡美;吉田さちね
• 通讯作者: 吉田さちね

The ontogenic analysis of expression of vesicular glutamate transporter during postnatal development of rat pineal gland

大鼠松果体出生后发育过程中囊泡谷氨酸转运蛋白表达的个体发育分析

• 发表时间: 2008
• 作者: 林真由美;中村昭代鹿野佐代子;田中洋介;田中洋介;坂野聡美;坂野聡美;吉田さちね;吉田さちね
• 通讯作者: 吉田さちね

Behavioral and anatomical characterization of mouse pup response to maternal transport.

小鼠幼崽对母体运输反应的行为和解剖学特征。

• 作者: Yoshida S;Kikusui T;Kato T;Kuroda KO
• 通讯作者: Kuroda KO