Transport Response in mammalian young: Analysis of neuromolecular mechanism

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A mother carries the young in many altricial mammals. Meanwhile, the transported young immediately assume a compact posture and stay calm. This young's response to maternal transport is called "Transport Response (TR)". We studied the postnatal development and regulatory mechanisms of TR using mouse pups. We found that TR was an intricate combination of immobilization and postural regulation. Tactile sensation and proprioception were essential for immobilization component of TR. The postural regulation component of TR was dependent on the cerebellar function. These findings indicate that TR is a filial-specific response that involves multiple brain areas for its regulation.