Finding the novel anti-metabolic syndrome treatment by examining the mechanism of improvement for lipid metabolism with hyperbaric oxygen.

通过研究高压氧改善脂质代谢的机制来寻找新的抗代谢综合征治疗方法。

• 批准号: 21500685
• 负责人: HOSAKA Toshio
• 金额: $ 3万
• 依托单位: Saitama Medical University (2011)The University of Tokushima (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500685/
• 关键词: 生活習慣病; 高圧酸素療法; 脂質代謝; 糖代謝; アディポカイン; フディポカイン

Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after chronic treatments with HBA(hyperbaric air). The mRNA expressions related to lipid metabolism were significantly up-regulated in the muscle and liver. Increases in adipocytokine mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with obesity and metabolic syndrome and then, belong to the finding of new targets of treatment.

血清游离脂肪酸和甘油三酯水平显着下降，但没有葡萄糖和胰岛素，慢性治疗后与HBA（高压空气）。与脂质代谢相关的mRNA在肌肉和肝脏中表达显著上调。脂肪细胞因子mRNA的增加，损害脂质代谢，也被HBA治疗减弱。这些结果表明，HBA暴露可能对肥胖和代谢综合征患者的脂代谢产生有益的影响，从而属于新的治疗靶点的发现。

项目成果

加圧空気療法(Hyperbaric air therapy : HBAT)は糖尿病マウスの脂質異常症を改善する

高压空气疗法（HBAT）可改善糖尿病小鼠的血脂异常

• 发表时间: 2010
• 作者: 山口美輪;保坂利男;勅使川原匡;寺田依里;福永恵子;西脇由佳;平田容子;酒井徹;中屋豊
• 通讯作者: 中屋豊

Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

长期高压空气治疗改善db/db小鼠高脂血症

• 发表时间: 2010
• 期刊: The journal of medical investigation
• 作者: Kiyoshi Teshigawara;Toshio Hosaka;Miwa Yamaguchi;Eri Terada;Yuka kisyuku;Keiko Fukunaga;Yohko Hirata;Bayasgalan Jambaldorj;Nagakatsu Harada;Tohru Sakai and Yutaka Nakaya
• 通讯作者: Tohru Sakai and Yutaka Nakaya

加圧空気治療(Hyperbaric air therapy : HBAT)の糖脂質代謝への影響の検討

检查高压空气疗法（HBAT）对糖脂代谢的影响

• 发表时间: 2008
• 作者: 山口美輪;勅使川原匡;寺田依里;福永恵子;西脇由佳;Li Qinkai;平田容子;船木真理;中屋豊;保坂利男
• 通讯作者: 保坂利男

Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression

• DOI: 10.1016/j.bbrc.2009.10.015
• 发表时间: 2009-12-18
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Chung, Le Thi Kim;Hosaka, Toshio;Nakaya, Yutaka
• 通讯作者: Nakaya, Yutaka

Heparin-Binding EGF-Like Growth Factor (HB-EGF) Mediates 5-HT-Induced Insulin Resistance Through Activation of EGF Receptor-ERK1/2-mTOR Pathway

• DOI: 10.1210/en.2011-1418
• 发表时间: 2012-01-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Li, Qinkai;Hosaka, Toshio;Funaki, Makoto
• 通讯作者: Funaki, Makoto