A comprehensive search for antiangiogenic food factors and molecular biological analysis of their mode of inhibition

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In recent years, it has been shown that for solid tumors to grow continuously they need constant supply of nutrients and oxygen from the blood and they induce angiogenesis, a local expansion of blood vessel network, to achieve that go al. It has also been shown that inhibition of such tumor angiogenesis is a new and very effective strategy for cancer treatment. As an application of this new cancer-treating strategy, a basic research toward developing antiangiogenic foods that can be used to prevent cancer was conducted. As a result, various plant extracts and their active ingredients were shown to possess antiangiogenic activities and their modes of inhibition were compared.