Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A

双酚A暴露后P19神经元转录组和DNA甲基化的变化

• 批准号: 21510072
• 负责人: YAOI Takeshi
• 金额: $ 3.16万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21510072/
• 关键词: 内分泌かく乱物; エピジェネティクス; 発生・分化; 脳・神経; 環境化学物質; 環境エピジェネティクス; 内分泌かく乱物質

It was revealed that the exposure to one of the "non-toxic" BPA metabolites could elicit both epigenetic mutations and perturbation of transcriptome in mouse P19 neurons. The differentially expressed genes were highly significantly enriched for the BPA-responsive gene set. mRNA expression of most of them was also altered in the fetal forebrain maternally exposed to BPA. These data suggested that the metabolite was one of the potent bioactive forms of BPA molecule in the BPA-exposed fetal brain.

结果表明，暴露于一种“无毒”BPA代谢物可以引起小鼠P19神经元的表观遗传突变和转录组扰动。差异表达的基因高度显着富集BPA响应基因集。在母体暴露于BPA的胎儿前脑中，它们中大多数的mRNA表达也发生了变化。这些数据表明，代谢产物是BPA暴露的胎脑中BPA分子的有效生物活性形式之一。

项目成果

胎生期にBisphenol A曝露されたマウス終脳におけるDNAメチル化変動

胚胎期接触双酚A的小鼠端脑DNA甲基化变化

• 发表时间: 2009
• 作者: 矢追毅;伊東恭子;中村惠子;伏木信次
• 通讯作者: 伏木信次

Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain

• DOI: 10.1088/0957-4484/21/33/335103
• 发表时间: 2010-08-20
• 期刊: NANOTECHNOLOGY
• 影响因子: 3.5
• 作者: Kato, Shingo;Itoh, Kyoko;Fushiki, Shinji
• 通讯作者: Fushiki, Shinji

Prenatal and Lactational Exposure to Bisphenol A in Mice Alters Expression of Genes Involved in Cortical Barrel Development without Morphological Changes.

• DOI: 10.1267/ahc.10042
• 发表时间: 2011-02-26
• 期刊: Acta histochemica et cytochemica
• 影响因子: 2.4
• 作者: Han L;Itoh K;Yaoi T;Moriwaki S;Kato S;Nakamura K;Fushiki S
• 通讯作者: Fushiki S

Bisphenol A, an endocrine-disrupting chemical, and brain development

• DOI: 10.1111/j.1440-1789.2011.01287.x
• 发表时间: 2012-08-01
• 期刊: NEUROPATHOLOGY
• 影响因子: 2.3
• 作者: Itoh, Kyoko;Yaoi, Takeshi;Fushiki, Shinji
• 通讯作者: Fushiki, Shinji

エピジェネティクスの研究方法

表观遗传学研究方法

• 发表时间: 2009
• 期刊: 京都府立医科大学雑誌 118
• 作者: Tomida J;Masuda Y;Hiroaki H;Ishikawa T;Song I;Tsurimoto T;Tateishi S;Shiomi T;Kamei Y;Kim J;Kamiya K;Vaziri C;Ohmori H;Todo T.;矢追毅
• 通讯作者: 矢追毅