Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A
Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A
批准号:
21510072
负责人:
YAOI Takeshi
金额:
$3.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
It was revealed that the exposure to one of the "non-toxic" BPA metabolites could elicit both epigenetic mutations and perturbation of transcriptome in mouse P19 neurons. The differentially expressed genes were highly significantly enriched for the BPA-responsive gene set. mRNA expression of most of them was also altered in the fetal forebrain maternally exposed to BPA. These data suggested that the metabolite was one of the potent bioactive forms of BPA molecule in the BPA-exposed fetal brain.
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胎生期にBisphenol A曝露されたマウス終脳におけるDNAメチル化変動
胚胎期接触双酚A的小鼠端脑DNA甲基化变化
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[矢追毅, 伊東恭子, 中村惠子, 伏木信次]
通讯作者:
伏木信次
DOI:
10.1088/0957-4484/21/33/335103
发表时间:
2010-08-20
期刊:
NANOTECHNOLOGY
影响因子:
3.5
作者:
[Kato, Shingo, Itoh, Kyoko, Fushiki, Shinji]
通讯作者:
Fushiki, Shinji
DOI:
10.1267/ahc.10042
发表时间:
2011-02-26
期刊:
Acta histochemica et cytochemica
影响因子:
2.4
作者:
[Han L, Itoh K, Yaoi T, Moriwaki S, Kato S, Nakamura K, Fushiki S]
通讯作者:
Fushiki S
DOI:
10.1111/j.1440-1789.2011.01287.x
发表时间:
2012-08-01
期刊:
NEUROPATHOLOGY
影响因子:
2.3
作者:
[Itoh, Kyoko, Yaoi, Takeshi, Fushiki, Shinji]
通讯作者:
Fushiki, Shinji
エピジェネティクスの研究方法
表观遗传学研究方法
DOI:
--
发表时间:
2009
期刊:
京都府立医科大学雑誌 118
影响因子:
--
作者:
[Tomida J, Masuda Y, Hiroaki H, Ishikawa T, Song I, Tsurimoto T, Tateishi S, Shiomi T, Kamei Y, Kim J, Kamiya K, Vaziri C, Ohmori H, Todo T., 矢追毅]
通讯作者:
矢追毅
共 6 条
Dose the fetal exposure to environmental chemicals have a impact on the alternative splicing profiles in post weaning brain via its epigenetic changes ?
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批准号:25550039
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.75万
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财政年份:2013
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负责人:YAOI Takeshi
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依托单位:
海外基金