The effect of behavior therapy in obsessive compulsive disorder using both a voxel-based morphometry approach and neuropsychological tasks

在这项研究中，我们使用基于体素的形态计量学(VBM)方法检测了强迫症患者基线时灰质(GM)和白质(WM)局部结构异常的存在，这些患者对随后的BT有效和无效。此外，我们还用神经心理学的方法检查了这些异常。T1加权磁共振成像研究是在12周BT完成之前进行的。与应答者相比，无应答者右侧前额叶腹内侧皮质、右侧眶前叶皮质(OFC)、右侧前扣带回皮质(ACC)的GM体积明显减小。此外，与应答者相比，无应答者左侧扣带束、双侧扣带束的WM体积明显较小。两组在注意/执行功能上存在差异。这些结果表明，包括OFC、ACC和扣带束在内的几个区域的大脑结构与强迫症患者对BT缺乏反应有关。VBM方法的使用可能有利于了解应答者和非应答者之间的差异。

In this study, we examined the existence of regional structural abnormalities in both the gray matter(GM) and the white matter(WM) of patients with OCD at baseline using a voxel-based morphometry(VBM) approach in responders and non-responders to subsequent BT. In addition, we examined the abnormalities using neuropsychological approach. TheT1-weighted magnetic resonance imaging studies were performed before the completion of 12 weeks of BT. Relative to the responders, the non-responders exhibited significantly smaller GM volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex(OFC), the right anterior cingulate cortex(ACC). In addition, relative to the responders, the non-responders exhibited significantly smaller WM volumes in the left cingulate bundle, bilateral cingulate bundles. Two groups exhibited the difference on the part of the attention/executive functions. These results suggest that brain structures in several areas including the OFC, ACC, and cingulate bundles are related to the lack of a response to BT in patients with OCD. The use of a VBM approach may be advantageous to understanding differences between responders and non-responders.