Study on the Regulation Mechanism of Gelation in Biopolymer Gel associated with N-linked Carbohydrate Chain

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Following scheme of the fibrin gel formation mechanism was strongly suggested from the present study on the fibrin gel formation. Carbohydrate chain N-linked to the Bβ peptide chain that locates in the distal D region of fibrinogen molecule interacts with the N-terminal region of Bβ chain, and inhibits the aggregating action of it succeeding to the protofibril formation.αC domains that mediate the lateral aggregation of protofibrils are bound to the fibrinopeptide B, and the release of them might be affected by the interaction between carbohydrate chain and N-terminal region of Bβ chain. As a result, the switchover from the protofibril formation/growth to the lateral aggregation of protofibrils is regulated by the carbohydrate chain.