Development of highly selective inhibitors against individual MMPs

点击翻译按钮获取中文摘要

(1) We determined the crystal structure of the catalytic domain of MMP-2 in complex with decapeptide inhibitor APP-IP, and clarified its mode of the MMP-2-selective inhibition.(2) We designed a highly selective and strong inhibitor against MMP-2 by combining the MMP-2-selective peptide inhibitor APP-IP and physiological MMPs inhibitor TIMP-2.(3) We clarified the mechanism of the cholesterol sulfate-mediated alteration of the substrate preference of MMP-7 ; clarification of the mechanism provides the clue to develop MMP-7-selective inhibitors.