The relationship of collagen fiber content and hepatic stellate cell function in the liver.

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This study was performed to clarify the relationship of the collagen fiber content and the characteristics of hepatic stellate cells(HSCs) in the chicken liver. The collagen fiber content, distribution and activity of HSCs in the liver were larger in cocks than in hens. These differences between the sexes were not observed during the embryonic stage and confirmed at 8 weeks of age of post-hatching stage. It is suggested that estradiol may be affected to inhibit the collagen fiber synthesis in the HSCs in the female chicken liver.