Development of the prominent labeling reagents for LC/MS/MS and sensitive analysis of the biomolecules
Development of the prominent labeling reagents for LC/MS/MS and sensitive analysis of the biomolecules
批准号:
21590039
负责人:
SANTA Tomofumi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) is widely used method. In this research, several labeling reagents were synthesized to enhance the sensitivity and selectivity in LC/MS/MS. These reagents enabled sensitive analysis of the biomolecules such as diseases markers. These methods were useful for the screening of the inherited metabolic disorders.
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Novel approaching for the determination of methycitrate in dried blood spots (DBS) by liquid chromatography tandem mass spectrometry.
液相色谱串联质谱法测定干血斑 (DBS) 中甲基柠檬酸盐的新方法。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Al-Dirbashi OY, McIntosh N, McRoberts C, Rashed MS, Geraghty MT, Fisher L, Santa T, Chakraborty P.]
通讯作者:
Chakraborty P.
Analysis of3-hydroxyglutalic acid in dried urine spots by LC-MS/MS; application for the diagnosis of glutaric aciduria type 1.
采用 LC-MS/MS 分析干燥尿斑中的 3-羟基戊二酸;
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Al-Dirbashi OY, Kolker S, Ng D, Fisher L, Rupar T, Lepage N, Rashed MS, Santa T, Goodman SI, Geraghty MT, Zschocke J, Christensen E, Hoffmann GE, Chakraborty P.]
通讯作者:
Chakraborty P.
Novel approach for quantification of fatty acid markers of peroxisomal disorders by LC-MS/MS.
通过 LC-MS/MS 定量过氧化物酶体疾病脂肪酸标记物的新方法。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Al-Dirbashi, Osama Y]
通讯作者:
Osama Y
Isothiocyanates as derivatization reagents for amines in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS)
异硫氰酸盐作为液相色谱/电喷雾电离串联质谱 (LC/ESI-MS/MS) 中胺的衍生试剂
DOI:
--
发表时间:
2010
期刊:
Biomedical Chromatography
影响因子:
1.8
作者:
[Kohei Otomo, Akira Toyama, Takashi Miura, Hideo Takeuchi, Santa T]
通讯作者:
Santa T
DOI:
10.1002/ajmg.a.32874
发表时间:
2009-06-01
期刊:
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
影响因子:
2
作者:
[Al-Dirbashi, O. Y., Shaheen, R., Alkuraya, F. S.]
通讯作者:
Alkuraya, F. S.
共 8 条
Development of the prominent labeling reagent for LC/MS/MS and its application to the analysis of the biomolecules
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批准号:19590036
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:SANTA Tomofumi
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依托单位:
Development of microchip liquid chromatography for ultra-sensitive analysis of trace amounts of bio-molecules.
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批准号:17590030
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:SANTA Tomofumi
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依托单位:
Development of the sensitive determination method for the endogenous NO synthetase inhibitor and analysis of homeostasis of blood pressure.
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批准号:13672250
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2001
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负责人:SANTA Tomofumi
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依托单位:
Theoretical prediction of fluorescent characteristics and development of fluorogenic derivatization reagents
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批准号:11672137
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1999
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负责人:SANTA Tomofumi
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依托单位:
海外基金