Elucidation of the molecular basis attributed to onset of abnormal retinal hemodynamics and strategy of novel prevention drugs for retinopathy

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This study demonstrated that retinal vasodilator responses mediated through the mechanism involving activation of the large-conductance Ca^<2+>-activated K^+(BK_<Ca>) channel was diminished at the early stage of diabetes in rats. Furthermore, it was suggested that the oxydative stress was increased in retinal blood vessels of diabetes rats. Thus, impairment of BK_<Ca> channel function and increased oxidative stress may contribute to abnormal retinal hemodynamics in diabetes and consequently play an important role in the pathogenesis of diabetic retinopathy. In conclusion, drugs that improve retinal circulation and possess antioxidative effect are considered to be novel candidates for prevention of retinopathy.