Study on health risk assessment of chlorinated polycyclic aromatic hydrocarbons

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The standards of chlorinated and bromated benzo[a] pyrenes were produced by chemical modification. After purification, the purities of these compounds were 94.6% of mono-chlorinated B[a] P replaced on 6 position, 97.2% of mono-bromated B[a] P replaced on 6 position, 94.6% of di-chlorinated B[a] P mixtures replaced 6, 11-and 6, 13-positions. These halogenated B[a] Ps showed weak toxicities on the cells and mutagenecities under the condition of metabolic activation. However, there were results of indicating the possibility of adverse effects on the nerve development process. The abundance was very little.