A study for the role of bone marrow stromal cells in hematopoietic regulation

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The proliferation and differentiation of hematopoietic stem cells are regulated by bone marrow microenvironment. Stromal cells, as distinguished from hematopoietic cells, are an essential compartment of this microenvironment. In this study, the stromal cells are shown to regulate the proliferation and differentiation of hematopoietic cells through the mechanism by producing diffusible hematopoietic regulatory factors. Further, a novel in vitro three-dimensional(3D) hematopoietic culture system is developed, and the importance of stromal cells to regulate hematopoietic cell growth is also clarified.