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Studies on the mechanism of epithelial ion transport mediated by Chemical receptors expressed in the colonic mucosa

Studies on the mechanism of epithelial ion transport mediated by Chemical receptors expressed in the colonic mucosa
结肠粘膜化学受体介导的上皮离子转运机制研究
批准号:
21590235
负责人:
KUWAHARA Atsukazu
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Gut lumen is continually exposed to many agents, including noxious compounds. Chemical receptors that detect the luminal environment are thought to play an important role as sensors and as modulators of epithelial cell functions. In the present research, function of chemical sensors in the rat and human large intestine were investigated.
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会议论文
Free fatty acid receptors and their physiological roles in the colon
游离脂肪酸受体及其在结肠中的生理作用
DOI: --
发表时间: 2010
期刊: Medycyna Wet
影响因子: --
作者: [鈴木優子, 浦野哲盟, 影山晴秋, Karaki SI and Kuwahara A]
通讯作者: Karaki SI and Kuwahara A
Bitter taste receptor(T2R) ligand, 6-n-propyl-2-thiouracil(6-PTU)-evoked anion secretion in human and rat colon : interaction with COX-2 activity
苦味受体(T2R)配体,6-正丙基-2-硫尿嘧啶(6-PTU)诱发人和大鼠结肠中的阴离子分泌:与COX-2活性的相互作用
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kaji I, Karaki SI, Kuwahara A]
通讯作者: Kuwahara A
DOI: 10.1248/yakushi.131.1691
发表时间: 2011-12
期刊: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
影响因子: --
作者: [I. Kaji;Shin-Ichiro Karaki;A. Kuwahara]
通讯作者: I. Kaji;Shin-Ichiro Karaki;A. Kuwahara
下部消化管における化学受容について
关于下胃肠道的化学感受
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kito, Y., Sanders, K.M., Ward, S.M., Suzuki, H., 唐木晋一郎]
通讯作者: 唐木晋一郎
37
    Regulation of ion transpot by short chain fatty acids receptor, GPR43 in colonic epithelia
    • 批准号:
      18590207
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.57万
    • 财政年份:
      2006
    • 负责人:
      KUWAHARA Atsukazu
    • 依托单位:
    Analysis of the intracellular second messenger pathway in the intestinal epithelial cell
    • 批准号:
      08044331
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $5.82万
    • 财政年份:
      1996
    • 负责人:
      KUWAHARA Atsukazu
    • 依托单位:
    Regulation of water and electrolyte transport in the gut
    海外基金