课题基金 / 基金详情

Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns

Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns
CIN85基因敲除小鼠多动及忽视新生儿的行为障碍及抢救不足分析
批准号:
21590251
负责人:
SIMOKAWA Noriaki
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

项目摘要

项目成果

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Cbl-interacting protein of 85 kDa (CIN85) is an adaptor protein implicated in the regulation of receptor trafficking and cell division. CIN85 knockout (CIN85 KO) mice displayed a hyperactivity phenotype. In CIN85 KO, the recruitment of the endocytic machinery required for D2DR endocytosis is diminished. Our findings indicate an important role of CIN85 in the regulation of dopamine receptor functions and provide new insight into a molecular explanation for hyperactive behavior.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The effect of lipopolysaccharide on astrocyte plasticity.
脂多糖对星形胶质细胞可塑性的影响。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Xu Ming, Toshiharu Iwasaki, Noriaki Shimokawa, Noriyuki Koibuchi]
通讯作者: Noriyuki Koibuchi
Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat
先天性甲状腺功能减退(rdw)大鼠的小脑功能障碍和行为障碍
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yamaguchi S, Ohsawa A, Yousefi B, Morioka S, Masuda H, Ronny, Hayashi H, Takatsuru Y, Iwasaki T, Shimokawa N, Umezu M, Koibuchi N]
通讯作者: Koibuchi N
Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) τ in breast cancer cells: identification of a novel for response element
乳腺癌细胞中视黄酸受体相关孤儿受体 (ROR) τ 激活芳香酶表达:鉴定一种新型反应元件
DOI: --
发表时间: 2009
期刊: J. Biol. Chem
影响因子: --
作者: [Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N]
通讯作者: Koibuchi N
Recent progress of the effect of Bromo-related environmental chemicals on thyroid hormone-related normal brain development
溴相关环境化学物质对甲状腺激素相关正常脑发育影响的最新进展
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [岩崎俊晴, イブハゼヒエボ キングスレイ, 原口瑞樹, 徐明, 下川哲昭, 鯉淵典之]
通讯作者: 鯉淵典之
47
    海外基金