Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns

CIN85基因敲除小鼠多动及忽视新生儿的行为障碍及抢救不足分析

• 批准号: 21590251
• 负责人: SIMOKAWA Noriaki
• 金额: $ 3万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590251/
• 关键词: CIN85; 多動性; ドーパミン受容体; エンドサイトーシス; ノックアウトマウス; 哺育行動; ドーパミン; プロラクチン; 視床下部

Cbl-interacting protein of 85 kDa (CIN85) is an adaptor protein implicated in the regulation of receptor trafficking and cell division. CIN85 knockout (CIN85 KO) mice displayed a hyperactivity phenotype. In CIN85 KO, the recruitment of the endocytic machinery required for D2DR endocytosis is diminished. Our findings indicate an important role of CIN85 in the regulation of dopamine receptor functions and provide new insight into a molecular explanation for hyperactive behavior.

分子量为85 kDa的Cbl-interacting protein（CIN 85）是一种衔接蛋白，参与受体运输和细胞分裂的调节。CIN 85基因敲除（CIN 85 KO）小鼠表现出多动表型。在CIN 85 KO中，D2 DR内吞作用所需的内吞机制的募集减少。我们的研究结果表明，CIN 85在调节多巴胺受体功能中的重要作用，并为多动行为的分子解释提供了新的见解。

项目成果

Cerebellar dysfunction and behavioral disorder in congenital hypothyroid (rdw) rat

先天性甲状腺功能减退（rdw）大鼠的小脑功能障碍和行为障碍

• 发表时间: 2011
• 作者: Yamaguchi S;Ohsawa A;Yousefi B;Morioka S;Masuda H;Ronny;Hayashi H;Takatsuru Y;Iwasaki T;Shimokawa N;Umezu M;Koibuchi N
• 通讯作者: Koibuchi N

The effect of lipopolysaccharide on astrocyte plasticity.

脂多糖对星形胶质细胞可塑性的影响。

• 发表时间: 2010
• 作者: Xu Ming;Toshiharu Iwasaki;Noriaki Shimokawa;Noriyuki Koibuchi
• 通讯作者: Noriyuki Koibuchi

Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) τ in breast cancer cells: identification of a novel for response element

乳腺癌细胞中视黄酸受体相关孤儿受体 (ROR) τ 激活芳香酶表达：鉴定一种新型反应元件

• 发表时间: 2009
• 期刊: J. Biol. Chem
• 作者: Odawara H;Iwasaki T;Horiguchi J;Rokutanda N;Hirooka K;Miyazaki W;Koibuchi Y;Shimokawa N;Iino Y;Takeyoshi I;Koibuchi N
• 通讯作者: Koibuchi N

Recent progress of the effect of Bromo-related environmental chemicals on thyroid hormone-related normal brain development

溴相关环境化学物质对甲状腺激素相关正常脑发育影响的最新进展

• 发表时间: 2012
• 作者: 岩崎俊晴;イブハゼヒエボ キングスレイ;原口瑞樹;徐明;下川哲昭;鯉淵典之
• 通讯作者: 鯉淵典之

Student laboratory practice through MD-PhD course

通过医学博士课程的学生实验室实践

• 发表时间: 2009
• 作者: Koibuchi N.;Iwasaki T.;Shimokawa N
• 通讯作者: Shimokawa N