Neurotransmitters that regulate prostaglandin E2-induced fever in the region surrounding the organum vasculosum of the lamina terminalis

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Prostaglandin E_2-induced fever is established by simultaneous activation of heat production and reduction of heat loss. On the other hand, hypoxic stimulation nduces hypothermia that is caused by an increase in heat loss and a decrease in heat production. Both responses are regulated by mechanisms in the region surrounding the organum vasculosum of the lamina terminalis in the hypothalamus. It was elucidated that the hypoxia-induced responses were mediated by noradrenaline released in this region in anesthetized rats. They were then mediated by synthesis and release of nitric oxide via stimulation of α_1-adrenoceptors in the same region. Then, it was proposed that a glutamatergic projection from this region to the lateral preoptic area is critically involved in the responses