Neurotransmitters that regulate prostaglandin E2-induced fever in the region surrounding the organum vasculosum of the lamina terminalis

调节终板血管器官周围区域前列腺素 E2 引起的发热的神经递质

• 批准号: 21590265
• 负责人: OSAKA Toshimasa
• 金额: $ 3.08万
• 依托单位: National Institute of Health and Nutrition
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590265/
• 关键词: 体温調節; 視床下部; プロスタグランジン; ノルアドレナリン; 一酸化窒素; 低酸素環境; エネルギー代謝; 視索前野; 発熱; グルタミン酸; GABA; 酸素消費率; 外側視索前野; 熱放散; 非ふるえ熱産生; プロスタグランジンE2

Prostaglandin E_2-induced fever is established by simultaneous activation of heat production and reduction of heat loss. On the other hand, hypoxic stimulation nduces hypothermia that is caused by an increase in heat loss and a decrease in heat production. Both responses are regulated by mechanisms in the region surrounding the organum vasculosum of the lamina terminalis in the hypothalamus. It was elucidated that the hypoxia-induced responses were mediated by noradrenaline released in this region in anesthetized rats. They were then mediated by synthesis and release of nitric oxide via stimulation of α_1-adrenoceptors in the same region. Then, it was proposed that a glutamatergic projection from this region to the lateral preoptic area is critically involved in the responses

前列腺素E_2引起的发热是通过同时激活产热和减少热损失而建立的。另一方面，低氧刺激引起体温降低，这是由热损失增加和产热减少引起的。这两种反应都受到下丘脑终板血管器周围区域的机制调节。结果表明，在麻醉大鼠中，该区域释放的去甲肾上腺素介导了缺氧诱导的反应。然后通过刺激同一区域的α_1-肾上腺素受体合成和释放一氧化氮来介导。然后，有人提出，从该区域到外侧视前区的神经元投射在反应中起关键作用

项目成果

低酸素刺激によって誘起される低体温反応における視床下部視索前野の機構

下丘脑视前区缺氧刺激引起低温反应的机制

• 作者: Wang;H.H.;et al.;Sayaka Fujita;大坂寿雅
• 通讯作者: 大坂寿雅

HYPOXIA-INDUCED HYPOTHERMIA MEDIATED BY NORADRENALINE AND NITRIC OXIDE IN THE ROSTROMEDIAL PREOPTIC AREA

• DOI: 10.1016/j.neuroscience.2011.01.056
• 发表时间: 2011-04-14
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Osaka, T.

HEAT LOSS RESPONSES AND BLOCKADE OF PROSTAGLANDIN E2-INDUCED THERMOGENESIS ELICITED BY α1-ADRENERGIC ACTIVATION IN THE ROSTROMEDIAL PREOPTIC AREA

• DOI: 10.1016/j.neuroscience.2009.05.030
• 发表时间: 2009-09-15
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Osaka, T.

低酸素刺激による低体温反応への視床下部終板器官周囲部のα1アドレナリン受容体と一酸化窒素の関与

下丘脑终板周围器官区α1-肾上腺素能受体和一氧化氮参与缺氧刺激引起的低温反应

• 发表时间: 2010
• 作者: Horio S;et al.;大坂寿雅
• 通讯作者: 大坂寿雅

終板器官周囲部でのノルアドレナリンの体温低下作用

去甲肾上腺素对终板器官周围的降温作用

• 发表时间: 2009
• 作者: Shahriar M;et al.;大坂寿雅
• 通讯作者: 大坂寿雅