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The elucidation of the mechanisms underlying anticancer drug-induced peripheral neuropathy and its prophylaxis.

The elucidation of the mechanisms underlying anticancer drug-induced peripheral neuropathy and its prophylaxis.
阐明抗癌药物引起的周围神经病变的机制及其预防。
批准号:
21590285
负责人:
OISHI Ryozo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The present study elucidated that the L type Ca2+ channels/NFAT/TRPM8 pathway plays a key role on oxaliplatin-induced cold hyperalgesia in rats, and Ca2+ channel blockers have prophylactic potential against that acute neuropathy caused by oxaliplatin. It was also found that the up-regulation of spinal NMDA receptor NR2B subunit involves in oxaliplatin-induced mechanical allodynia. Moreover, ifenfrodil and neurotropin could suppress the mechanical allodynia induced by oxaliplatin in rats.
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Involvement of spinal NR2B-containing NMDA receptor in oxaliplatin-induced mechanical allodynia in rats.
含有 NR2B 的脊髓 NMDA 受体参与奥沙利铂诱导的大鼠机械异常性疼痛。
DOI: --
发表时间: 2011
期刊: Molecular Pain
影响因子: 3.3
作者: [Mihara, et al.]
通讯作者: et al.
オキサリプラチン誘発末梢神経障害に対する牛車腎気丸の改善作用
Goshajinkigan 对奥沙利铂引起的周围神经病变的改善作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [牛尾聡一郎, ほか]
通讯作者: ほか
オキサレート基はラットにおいてオキサリプラチン誘発低温知覚異常には関与するが,機械的アロディニアには関与しない
草酸盐基团参与奥沙利铂诱导的大鼠冷感觉异常,但不参与大鼠机械性异常性疼痛
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [川尻雄大, 江頭伸昭, 櫻井万理子, 矢野貴久, 池末裕明, 大石了三]
通讯作者: 大石了三
DOI: 10.1186/1744-8069-7-8
发表时间: 2011-01-20
期刊: Molecular pain
影响因子: 3.3
作者: [Mihara Y, Egashira N, Sada H, Kawashiri T, Ushio S, Yano T, Ikesue H, Oishi R]
通讯作者: Oishi R
29
    The elucidation of the mechanisms underlying antimicrobial agents-induced nephrotoxicity
    • 批准号:
      19590252
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2007
    • 负责人:
      OISHI Ryozo
    • 依托单位:
    The elucidation of the mechanisms underlying contrast media induced nephrotoxicity and its prophylaxis.
    • 批准号:
      17590471
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      OISHI Ryozo
    • 依托单位:
    Involvements of NO and histamine in radiographic contrast medium-induced pulmonary dysfunction
    • 批准号:
      13672390
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2001
    • 负责人:
      OISHI Ryozo
    • 依托单位:
    海外基金