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Drug development using accelerated aging model

Drug development using accelerated aging model
使用加速老化模型进行药物开发
批准号:
21590289
负责人:
KOSHIMIZU Taka-aki
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Vasopressin is known to promote cellular growth and protein synthesis in adrenocortical and other cell types. We examined the role of V1a receptor in steroid secretion and cellular aging in adrenal cortex. In adrenocortical cell line, vasopressin promoted glucocorticoid secretion when applied alone or together with adrenocortical hormone. This study also found that V1a knockout mouse is an excellent model for studying aging in adrenocortical cells.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Sanbe A., et al, 輿水崇鏡]
通讯作者: 輿水崇鏡
Critical roles of V1a and V1b vasopressin receptors in systemic blood pressure Homeostasis : studies from gene knockout mice
V1a 和 V1b 加压素受体在全身血压稳态中的关键作用:基因敲除小鼠的研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Koshimizu T, et.al.]
通讯作者: et.al.
DOI: 10.1016/j.bbrc.2010.01.089
发表时间: 2010-02-19
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Koshimizu, Taka-aki, Tsuchiya, Hiroyoshi, Fujimura, Akio]
通讯作者: Fujimura, Akio
DOI: 10.1038/nature10798
发表时间: 2012-03-15
期刊: NATURE
影响因子: 64.8
作者: [Ichimura, Atsuhiko, Hirasawa, Akira, Froguel, Philippe]
通讯作者: Froguel, Philippe
6
    Research and application of allosteric ligands directed to G-protein coupled receptor heteromers
    • 批准号:
      24590327
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      KOSHIMIZU Taka-aki
    • 依托单位:
    海外基金