Quantitative analysis of fundus autofluorescence based on an excitation wavelength of 532nm.

基于 532nm 激发波长的眼底自发荧光定量分析。

• 批准号: 23791996
• 负责人: KOJIMA Akira
• 金额: $ 1.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791996/
• 关键词: 臨床研究; 眼底自発蛍光; 加齢黄斑変性; 中心性漿液性脈絡網膜症; リポフスチン; キサントフィル

Fundus autofluorescence images based on an excitation wavelength of 532nm (532AF) were acquired using modified scanning laser ophthalmoscope: F-10 (NIDEK, Aichi, Japan). The findings of 532AF in normal eyes and pathologic eyes were analyzed. 1) In normal eyes, fluorescent brightness distribution of 532AF was similar to that of autofluorescence based on 490nm excitation light (490AF). As 532nm light is only slightly blocked by macular pigments, foveal autofluorescence was well observed by 532AF. 2) Abnormal findings of 532AF were observed in eyes with central serous chorioretinopathy. Hyper-532AF was observed in the area with serous retinal detachment (SRD) and resolved SRD where outer retina was damaged. Hypo-532AF was seen in the area with damaged retinal pigment epithelium. 3) Reference fluorescent tip was installed inside of the modified F-10 for quantitative analysis of 532AF. 532AF brightness of both fundus and reference tip were compared and analyzed. The data were under investigation now.

采用改良扫描激光检眼镜F-10 （NIDEK，爱知，日本）获得激发波长为532nm （532AF）的眼底自体荧光图像。分析532AF在正常眼和病理眼的表现。1)在正常人眼中，532AF的荧光亮度分布与基于490nm激发光（490AF）的自身荧光相似。由于532nm光仅被黄斑色素轻微遮挡，532AF能很好地观察到中央凹自身荧光。2)在中枢性浆液性脉络膜视网膜病变中观察到532AF的异常表现。Hyper-532AF见于浆液性视网膜脱离（SRD）区和外视网膜受损的溶解性SRD区。视网膜色素上皮受损区可见hypo532af。3)在改良后的F-10内部安装参考荧光针尖，用于532AF的定量分析。对比分析了眼底和参考尖端的亮度。目前正在调查这些数据。

项目成果

正常眼における532nm眼底自発蛍光の輝度分布

正常眼532nm眼底自发荧光亮度分布

• 作者: 小島 彰;菅野幸紀;伊勢重之;丸子一朗;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘

Tomohiro Iida Retromode imaging in confocal scanning laser ophthalmoscope for myopic retinoschisis and X-linked juvenile retinoschisis

Tomohiro Iida 在共焦扫描激光检眼镜中进行复古模式成像治疗近视视网膜劈裂和 X 连锁青少年视网膜劈裂

• 发表时间: 2012
• 作者: Yukinori Sugano;Ichiro Maruko;Akira Ojima;Tetsuju Sekiryu
• 通讯作者: Tetsuju Sekiryu

Fundus autofluorescence and optical coherence tomography findings in branch retinal vein occlusion.

• DOI: 10.1155/2012/638064
• 发表时间: 2012
• 期刊: Journal of ophthalmology
• 影响因子: 1.9
• 作者: Sekiryu T;Iida T;Sakai E;Maruko I;Ojima A;Sugano Y
• 通讯作者: Sugano Y

Demographic features of idiopathic macular telangiectasia in Japanese patients

• DOI: 10.1007/s10384-011-0112-5
• 发表时间: 2012-03-01
• 期刊: JAPANESE JOURNAL OF OPHTHALMOLOGY
• 影响因子: 2.4
• 作者: Maruko, Ichiro;Iida, Tomohiro;Sekiryu, Tetsuju
• 通讯作者: Sekiryu, Tetsuju

黄斑部脈絡膜母斑に対する近赤外光観察と自発蛍光所見

黄斑脉络膜痣的近红外光观察及自发荧光表现

• 发表时间: 2012
• 作者: 古田 実;小島 彰;板垣可奈子;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘