Quantitative analysis of fundus autofluorescence based on an excitation wavelength of 532nm.

基于 532nm 激发波长的眼底自发荧光定量分析。

• 批准号: 23791996
• 负责人: KOJIMA Akira
• 金额: $ 1.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791996/
• 关键词: 臨床研究; 眼底自発蛍光; 加齢黄斑変性; 中心性漿液性脈絡網膜症; リポフスチン; キサントフィル

Fundus autofluorescence images based on an excitation wavelength of 532nm (532AF) were acquired using modified scanning laser ophthalmoscope: F-10 (NIDEK, Aichi, Japan). The findings of 532AF in normal eyes and pathologic eyes were analyzed. 1) In normal eyes, fluorescent brightness distribution of 532AF was similar to that of autofluorescence based on 490nm excitation light (490AF). As 532nm light is only slightly blocked by macular pigments, foveal autofluorescence was well observed by 532AF. 2) Abnormal findings of 532AF were observed in eyes with central serous chorioretinopathy. Hyper-532AF was observed in the area with serous retinal detachment (SRD) and resolved SRD where outer retina was damaged. Hypo-532AF was seen in the area with damaged retinal pigment epithelium. 3) Reference fluorescent tip was installed inside of the modified F-10 for quantitative analysis of 532AF. 532AF brightness of both fundus and reference tip were compared and analyzed. The data were under investigation now.

使用改良的扫描激光眼镜：F-10（NIDEK，日本AICHI），基于532nm（532AF）的激发波长（532AF）的激发波长（532AF）图像。分析了正常眼睛和病理眼中532AF的发现。 1）在正常眼中，基于490nm激发光（490AF），荧光亮度分布与自动荧光相似。由于532nm的光仅被黄斑色素略微阻断，因此532AF很好地观察到了凹起的自动荧光。 2）在患有中央浆液性脉络膜炎的眼睛中观察到532AF的异常发现。在具有浆液性视网膜脱离（SRD）的区域观察到了Hyper-532AF，并在视网膜外部损坏的地方分辨出了SRD。在视网膜色素上皮受损的区域可见下降。 3）在修改后的F-10内安装参考荧光尖端，以进行532AF的定量分析。比较和分析了眼底和参考尖端的532AF亮度。数据正在研究中。

项目成果

正常眼における532nm眼底自発蛍光の輝度分布

正常眼532nm眼底自发荧光亮度分布

• 作者: 小島 彰;菅野幸紀;伊勢重之;丸子一朗;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘

Tomohiro Iida Retromode imaging in confocal scanning laser ophthalmoscope for myopic retinoschisis and X-linked juvenile retinoschisis

Tomohiro Iida 在共焦扫描激光检眼镜中进行复古模式成像治疗近视视网膜劈裂和 X 连锁青少年视网膜劈裂

• 发表时间: 2012
• 作者: Yukinori Sugano;Ichiro Maruko;Akira Ojima;Tetsuju Sekiryu
• 通讯作者: Tetsuju Sekiryu

Demographic features of idiopathic macular telangiectasia in Japanese patients

• DOI: 10.1007/s10384-011-0112-5
• 发表时间: 2012-03-01
• 期刊: JAPANESE JOURNAL OF OPHTHALMOLOGY
• 影响因子: 2.4
• 作者: Maruko, Ichiro;Iida, Tomohiro;Sekiryu, Tetsuju
• 通讯作者: Sekiryu, Tetsuju

Fundus autofluorescence and optical coherence tomography findings in branch retinal vein occlusion.

• DOI: 10.1155/2012/638064
• 发表时间: 2012
• 期刊: Journal of ophthalmology
• 影响因子: 1.9
• 作者: Sekiryu T;Iida T;Sakai E;Maruko I;Ojima A;Sugano Y
• 通讯作者: Sugano Y

黄斑部脈絡膜母斑に対する近赤外光観察と自発蛍光所見

黄斑脉络膜痣的近红外光观察及自发荧光表现

• 发表时间: 2012
• 作者: 古田 実;小島 彰;板垣可奈子;石龍鉄樹;飯田知弘
• 通讯作者: 飯田知弘