Biological significance of bone marrow-derived mesenchymal stem cells in tumor microenvironment

骨髓间充质干细胞在肿瘤微环境中的生物学意义

• 批准号: 21590370
• 负责人: SEMBA Shuho
• 金额: $ 3.16万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590370/
• 关键词: がん幹細胞; 骨髄由来間葉系幹細胞; がん微小環境; 胃癌; 大腸癌; Wnt5a; TGF-β; Snail; WNT5A; 上皮間葉移行; CD133

Bone marrow-derived mesenchymal stem cells-mediated activations of the WNT and TGF-βsignaling pathways were thought to provide advantageous microenvironments for cancer progression by supporting the re-acquisition and maintenance of cancer stem cells.

骨髓来源的间充质干细胞介导的WNT和TGF-β信号通路的激活被认为通过支持癌症干细胞的再获得和维持而为癌症进展提供有利的微环境。

项目成果

胃癌細胞と線維芽細胞・間葉系幹細胞の相互作用

胃癌细胞、成纤维细胞和间充质干细胞之间的相互作用

• 发表时间: 2012
• 期刊: 胃がんperspective
• 作者: Sasaki M;(他5名);仙波秀峰
• 通讯作者: 仙波秀峰

Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas

• DOI: 10.1038/sj.bjc.6604986
• 发表时间: 2009-04-28
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Nakayama, S.;Semba, S.;Yokozaki, H.
• 通讯作者: Yokozaki, H.

Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells.

• DOI: 10.1038/sj.bjc.6605309
• 发表时间: 2009-10-20
• 期刊: British journal of cancer
• 影响因子: 8.8

Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

• DOI: 10.1159/000325538
• 发表时间: 2011-01-01
• 期刊: PATHOBIOLOGY
• 影响因子: 5
• 作者: Hashimoto, Okito;Shimizu, Kazuya;Hori, Yuichi
• 通讯作者: Hori, Yuichi