Elucidation of genomic aberrations involved in recurrence and metastasis of renal cell carcinoma

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We analyzed primary and metastatic lesions of renal cell carcinoma(RCC) by array based comparative genomic hybridization(CGH), using genomic DNA extracted from formalin-fixed, paraffin-embedded tissue samples. We identified some different genomic aberrations between two groups. Next, we analyzed the methylation profiles of promoter regions, and also examined gene expression profiles. As a result of these findings, we found that the patients with 9p loss in primary tumors showed significantly lower recurrence(metastasis) free survival rate than the patients without 9p loss. Two genes located in 9p were identified as a candidate gene associated with recurrence and metastasis in RCC.