Genome-wide microRNA expression profiling in gastric cancer

我们使用miRNA微阵列平台研究了胃癌中microRNA（miRNA）的表达谱，该平台覆盖了总共470种人类miRNA。通过比较浸润型和弥漫型胃癌组织中miRNA的表达谱（ANOVA P<0. 05）。05），我们不能鉴定出它们之间差异表达的任何miRNA，这表明在胃癌中，miRNA表达谱可能与组织病理学亚型无关。我们鉴定了39个在胃癌中差异表达的miRNAs，其中6个显著下调，另外33个显著上调。在6个下调的miRNA中，我们选择了3个，miR-375，miR-29 c和miR-148 a作为胃癌相关的miRNA。

We investigated expression profiles of microRNA(miRNA) in gastric carcinomas by use of a miRNA microarray platform covering a total of 470 human miRNAs. By comparing miRNA expression profiles between intestinal-type and diffuse-type gastric carcinomas(ANOVA P<0. 05), we could not identify any miRNAs differentially expressed between them, suggesting that, in gastric carcinomas, the miRNA expression profile might not be correlated with histopathologic subtypes. We identified 39 differentially expressed miRNAs in gastric carcinoma, of which 6 were significantly downregulated and the other 33 were upregulated. Among the 6 down-regulated miRNA, we selected 3, miR-375, miR-29c and miR-148a, as gastric cancer-related miRNA.