Identification of genomic aberrations responsible for chemosensitivity of anti-cancer drugs

鉴定导致抗癌药物化学敏感性的基因组畸变

• 批准号: 21200001
• 负责人: MORIYAMA Masatsugu
• 金额: $ 19.47万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21200001/
• 关键词: バイオインフォマティクス; アレイCGH; メチル化; トランスクリプトーム; microRNA; 抗がん剤感受性; がん化学療法; バイオインフォーマテイクス

We analyzed genomic aberrations (gene copy number aberrations, aberrant expressions of mRNA and microRNA) of gastric carcinomas, renal cell carcinomas and colon carcinomas using microarray. Our study revealed that 1) miR-375 is a tumor suppressor microRNA of gastric carcinoma; 2) Upregulated miR-210 in renal cell carcinomas brought about aneuploidy to carcinoma cells; and 3) Sav1 gene is a tumor suppressor gene of renal cell carcinoma.

我们利用基因芯片分析了胃癌、肾癌和结肠癌的基因组畸变（基因拷贝数畸变、mRNA和microRNA的异常表达）。我们的研究表明：1）miR-375是胃癌的抑癌microRNA; 2）miR-210在肾癌中表达上调导致癌细胞非整倍体; 3）Sav 1基因是肾癌的抑癌基因。

项目成果

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

• DOI: 10.1007/s10147-011-0348-6
• 发表时间: 2013-02-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Doi, Toshihiko;Hamaguchi, Tetsuya;Ohtsu, Atsushi
• 通讯作者: Ohtsu, Atsushi

A phase II study of biweekly mitomycin C and irinotecan combination therapy in patients with fluoropyrimidine-resistant advanced gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group (JCOG0109-DI Trial).

氟嘧啶耐药晚期胃癌患者每两周一次丝裂霉素 C 和伊立替康联合治疗的 II 期研究：来自日本临床肿瘤学组胃肠肿瘤学组的报告（JCOG0109-DI 试验）。

• 发表时间: 2011
• 期刊: Gastric Cancer.
• 作者: Hamaguchi T;Shirao K;Ohtsu A;Hyodo I;Arai Y;Takiuchi H;Fujii H;Yoshida M;Saito H;Denda T;Koizumi W;Iwase H;Boku N; Gastrointestinal Oncology Study Group of Japan Clinical Oncology Group.
• 通讯作者: Boku N; Gastrointestinal Oncology Study Group of Japan Clinical Oncology Group.

high gradeの淡明腎細胞癌ではHippoシグナルの異常がみられる

在高级别透明肾细胞癌中观察到 Hippo 信号异常。

• 发表时间: 2011
• 作者: 松浦恵子;ほか
• 通讯作者: ほか

Biological effect of miR-210 overexpression on renal carcinoma cells

miR-210过表达对肾癌细胞的生物学效应

• 发表时间: 2011
• 作者: 中田知里;ほか
• 通讯作者: ほか

GENOMIC COPY NUMBER LOSS AT 9P IS ASSOCIATED WITH METASTASIS OF RENAL CELL CARCINOMA

9P 基因组拷贝数丢失与肾细胞癌转移相关

• 发表时间: 2011
• 作者: 成松隆弘;ほか
• 通讯作者: ほか