Coagulation factor VII producing tumors and their release of microparticles with coagulation initiating capacity

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Physiological expression of blood coagulation factor VII(fVII) is generally restricted to hepatocytes. In the present study, we found that breast cancer tumor cells produce fVII ectopically, and release fVII containing microparticles(MPs) with a high coagulation initiating capacity into the microenvironment, especially under hypoxic condition. In addition, we partly clarified a novel regulatory mechanism of gene expression under hypoxia combined with depleted nutrients, which could be a target for new cancer therapies.