Analysis of mechanism to escape from immune surveillance in tumor

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Soluble ligands for NKG2D are involved in escape from immune surveillance in tumor. In this study, soluble H60c (sH60c), NKG2D ligand expressed mainly in skin, was detected in skin tumor and was significantly induced in skin carcinoma. To detect sH60c protein, two monoclonal antibodies specific for H60c were generated and developed ELISA system for sH60c by using these Abs. This study is expected to be helpful in a better understanding of mechanisms to escape from immune surveillance in tumor and useful for development of novel immune therapy.