Epidemiologic and experimental study to clarify involvement of heavy metals in Parkinson's disease

流行病学和实验研究阐明重金属与帕金森病的关系

• 批准号: 21590657
• 负责人: FUKUSHIMA Tetsuhito
• 金额: $ 2.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590657/
• 关键词: 予防医学; パーキンソン病; マンガン; 重金属; 培養心筋細胞; mRNA; 細胞死; ナイアシン; ビタミン; 培養神経細胞; 環境曝露; 患者対照研究; 中国

From the results of the case-control study in China comparing concentrations of metals and vitamins in blood and urine, excessive intake of iron and copper, accumulation of manganese, vitamin E/copper imbalance in intake, and vitamin B12 decrease by zinc deficiency in the body might be involved in the etiology of Parkinson's disease.Our experimental study using Mouse CD1 brain striatum neuronal cells suggests the possibility that manganese causes increased nicotinamide N-methyltransferase activity, thereby increasing 1-methylnicotinamide levels in the brain and bringing about neuron death.

从中国的病例对照研究结果来看，血和尿中金属和维生素的浓度，铁和铜的过量摄入，锰的积累，维生素E/铜的摄入量失衡，以及体内缺锌导致维生素B12的减少，可能与帕金森病的病因有关。我们利用小鼠CD1脑纹状体神经细胞进行的实验研究表明，锰可能导致烟酰胺N-甲基转移酶活性增加，从而增加脑中1-甲基烟酰胺的水平，导致神经元死亡。

项目成果

Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese

• DOI: 10.1007/s12199-011-0262-6
• 发表时间: 2012-09-01
• 期刊: Environmental Health and Preventive Medicine
• 影响因子: 4.7
• 作者: Mori, Yayoi;Sugawara, Akiko;Fukushima, Tetsuhito
• 通讯作者: Fukushima, Tetsuhito

Nutritional effects on depressive symptoms in Parkinson's disease patients.

营养对帕金森病患者抑郁症状的影响。

• 发表时间: 2012
• 作者: Fukuda Y;Harada T. Gender;Fukushima T. et al.
• 通讯作者: Fukushima T. et al.

Relationship between Blood Levels of Heavy Metals and Parkinson's Disease in China

• DOI: 10.1159/000255462
• 发表时间: 2010-01-01
• 期刊: NEUROEPIDEMIOLOGY
• 影响因子: 5.7
• 作者: Fukushima, Tetsuhito;Tan, Xiaodong;Kanda, Hideyuki
• 通讯作者: Kanda, Hideyuki

Serum Vitamins and Heavy Metals in Blood and Urine, and the Correlations among Them in Parkinson's Disease Patients in China

• DOI: 10.1159/000328253
• 发表时间: 2011-01-01
• 期刊: NEUROEPIDEMIOLOGY
• 影响因子: 5.7
• 作者: Fukushima, Tetsuhito;Tan, Xiaodong;Kanda, Hideyuki
• 通讯作者: Kanda, Hideyuki

Nutritional effects on depressive symptoms in Parkinson's disease Patients

营养对帕金森病患者抑郁症状的影响

• 发表时间: 2012
• 期刊: e-SPEN Journal
• 作者: Fukuda Y;Hiyoshi A;Fukushima T. et al.
• 通讯作者: Fukushima T. et al.